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Cortical thickness development of human primary visual cortex related to the age of blindness onset
Li, Qiaojun1,2; Song, Ming1,2; Xu, Jiayuan3; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5; Jiang Tianzi
2017-08-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号11期号:4页码:1029-1036
文章类型Article
摘要Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 x 10(-5)) and right hemispheres (F = 6.54, P = 2 x 10(-3)). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1.
关键词Primary Visual Cortex Cortical Thickness Blindness Age Of Blindness Onset Adolescence
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9576-8
关键词[WOS]HUMAN PREFRONTAL CORTEX ; ACTIVATION ; PERFORMANCE ; PLASTICITY ; AWARENESS ; SURFACE ; PERIOD
收录类别SCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301 ; 91432302 ; 81471380 ; 81101040)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000407840500011
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12496
专题脑网络组研究中心
通讯作者Jiang Tianzi
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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Li, Qiaojun,Song, Ming,Xu, Jiayuan,et al. Cortical thickness development of human primary visual cortex related to the age of blindness onset[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1029-1036.
APA Li, Qiaojun.,Song, Ming.,Xu, Jiayuan.,Qin, Wen.,Yu, Chunshui.,...&Jiang Tianzi.(2017).Cortical thickness development of human primary visual cortex related to the age of blindness onset.BRAIN IMAGING AND BEHAVIOR,11(4),1029-1036.
MLA Li, Qiaojun,et al."Cortical thickness development of human primary visual cortex related to the age of blindness onset".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1029-1036.
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