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Cortical thickness development of human primary visual cortex related to the age of blindness onset
Li, Qiaojun1,2; Song, Ming1,2; Xu, Jiayuan3; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5; Jiang Tianzi
Source PublicationBRAIN IMAGING AND BEHAVIOR
2017-08-01
Volume11Issue:4Pages:1029-1036
SubtypeArticle
AbstractBlindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 x 10(-5)) and right hemispheres (F = 6.54, P = 2 x 10(-3)). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1.
KeywordPrimary Visual Cortex Cortical Thickness Blindness Age Of Blindness Onset Adolescence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9576-8
WOS KeywordHUMAN PREFRONTAL CORTEX ; ACTIVATION ; PERFORMANCE ; PLASTICITY ; AWARENESS ; SURFACE ; PERIOD
Indexed BySCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; National Natural Science Foundation of China(91132301 ; 91432302 ; 81471380 ; 81101040)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000407840500011
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12496
Collection脑网络组研究中心
Corresponding AuthorJiang Tianzi
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Recommended Citation
GB/T 7714
Li, Qiaojun,Song, Ming,Xu, Jiayuan,et al. Cortical thickness development of human primary visual cortex related to the age of blindness onset[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(4):1029-1036.
APA Li, Qiaojun.,Song, Ming.,Xu, Jiayuan.,Qin, Wen.,Yu, Chunshui.,...&Jiang Tianzi.(2017).Cortical thickness development of human primary visual cortex related to the age of blindness onset.BRAIN IMAGING AND BEHAVIOR,11(4),1029-1036.
MLA Li, Qiaojun,et al."Cortical thickness development of human primary visual cortex related to the age of blindness onset".BRAIN IMAGING AND BEHAVIOR 11.4(2017):1029-1036.
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