CASIA OpenIR  > 中国科学院分子影像重点实验室
Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles
Peng, Dong1,2,3; Du, Yang3,4; Shi, Yiwen5; Mao, Duo6; Jia, Xiaohua3,4; Li, Hui3; Zhu, Yukun3; Wang, Kun3,4; Tian, Jie1,2,3,4
2016
发表期刊NANOSCALE
卷号8期号:30页码:14480-14488
文章类型Article
摘要Photoacoustic imaging and fluorescence molecular imaging are emerging as important research tools for biomedical studies. Photoacoustic imaging offers both strong optical absorption contrast and high ultrasonic resolution, and fluorescence molecular imaging provides excellent superficial resolution, high sensitivity, high throughput, and the ability for real-time imaging. Therefore, combining the imaging information of both modalities can provide comprehensive in vivo physiological and pathological information. However, currently there are limited probes available that can realize both fluorescence and photoacoustic imaging, and advanced biomedical applications for applying this dual-modality imaging approach remain underexplored. In this study, we developed a dual-modality photoacoustic-fluorescence imaging nanoprobe, ICG-loaded Au@SiO2, which was uniquely designed, consisting of gold nanorod cores and indocyanine green with silica shell spacer layers to overcome fluorophore quenching. This nanoprobe was examined by both PAI and FMI for in vivo imaging on tumor and ischemia mouse models. Our results demonstrated that the nanoparticles can specifically accumulate at the tumor and ischemic areas and be detected by both imaging modalities. Moreover, this dual-modality imaging strategy exhibited superior advantages for a precise diagnosis in different scenarios. The new nanoprobe with the dual-modality imaging approach holds great potential for diagnosis and stage classification of tumor and ischemia related diseases.
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1039/c6nr03809c
关键词[WOS]MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY ; GOLD NANORODS ; COMPUTED-TOMOGRAPHY ; INDOCYANINE GREEN ; LIMB ISCHEMIA ; STRATEGIES ; SILICA ; CANCER ; PROBES ; LIGHT
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2015CB755500 ; National Natural Science Foundation of China(81227901 ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Scientific Research and Equipment Development Project of the Chinese Academy of Sciences(YZ201359) ; 2014CB748600) ; 61231004 ; 81527805 ; 61401462)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000381417800018
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12627
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
5.Shanghai Jiao Tong Univ, Dept Biomed Engn, Shanghai 200240, Peoples R China
6.Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117576, Singapore
推荐引用方式
GB/T 7714
Peng, Dong,Du, Yang,Shi, Yiwen,et al. Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles[J]. NANOSCALE,2016,8(30):14480-14488.
APA Peng, Dong.,Du, Yang.,Shi, Yiwen.,Mao, Duo.,Jia, Xiaohua.,...&Tian, Jie.(2016).Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles.NANOSCALE,8(30),14480-14488.
MLA Peng, Dong,et al."Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles".NANOSCALE 8.30(2016):14480-14488.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Precise diagnosis in(5397KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Peng, Dong]的文章
[Du, Yang]的文章
[Shi, Yiwen]的文章
百度学术
百度学术中相似的文章
[Peng, Dong]的文章
[Du, Yang]的文章
[Shi, Yiwen]的文章
必应学术
必应学术中相似的文章
[Peng, Dong]的文章
[Du, Yang]的文章
[Shi, Yiwen]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。