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Altered structural connectome in adolescent socially isolated mice
Liu, Cirong1,2,3; Li, Yonghui1; Edwards, Timothy J.1; Kurniawan, Nyoman D.4; Richards, Linda J.1,5; Jiang, Tianzi1,2,3,6
Source PublicationNEUROIMAGE
2016-10-01
Volume139Pages:259-270
SubtypeArticle
AbstractSocial experience is essential for adolescent development and plasticity of social animals. Deprivation of the experience by social isolation impairs white matter microstructures in the prefrontal cortex. However, the effect of social isolation may involve highly distributed brain networks, and therefore cannot be fully explained by a change of a single region. Here, we compared the connectomes of adolescent socially-isolated mice and normal-housed controls via diffusion magnetic resonance imaging. The isolated mice displayed an abnormal connectome, characterized by an increase in degree and reductions in measures such as modularity, small-worldness, and betweenness. The increase in degree was most evident in the dorsolateral orbitofrontal cortex, entorhinal cortex, and perirhinal cortex. In a connection-wise comparison, we revealed that most of the abnormal edges were inter-modular and inter-hemispheric connections of the dorsolateral orbitofrontal cortex. Further tractography-based analyses and histological examinations revealed microstructural changes in the forceps minor and lateral-cortical tracts that were associated with the dorsolateral orbitofrontal cortex. These changes of connectomes were correlated with fear memory deficits and hyper-locomotion activities induced by social isolation. Considering the key role of the orbitofrontal cortex in social behaviors, adolescent social isolation may primarily disrupt the orbitofrontal cortex and its neural pathways thereby contributing to an abnormal structural connectome. (C) 2016 Elsevier Inc. All rights reserved.
KeywordBrain Network Connectome Structural Connectivity Diffusion Mri Orbitofrontal Cortex Social Deprivation
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroimage.2016.06.037
WOS KeywordPERIRHINAL CORTEX LESIONS ; DEVELOPING MOUSE-BRAIN ; LEFT-RIGHT ASYMMETRY ; ENTORHINAL CORTEX ; CONTEXTUAL FEAR ; HIPPOCAMPAL-FORMATION ; BASOLATERAL AMYGDALA ; DORSAL HIPPOCAMPUS ; PREFRONTAL CORTEX ; SENSITIVE PERIOD
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 program)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301) ; National Health and Medical Research Council (NHMRC) Australia(1043045) ; NHMRC Principal Research Fellowship ; Australian Government ; Queensland State Government through Queensland NMR Network(16.4T)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000381583500026
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12643
Collection脑网络组研究中心
Affiliation1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia
5.Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
Recommended Citation
GB/T 7714
Liu, Cirong,Li, Yonghui,Edwards, Timothy J.,et al. Altered structural connectome in adolescent socially isolated mice[J]. NEUROIMAGE,2016,139:259-270.
APA Liu, Cirong,Li, Yonghui,Edwards, Timothy J.,Kurniawan, Nyoman D.,Richards, Linda J.,&Jiang, Tianzi.(2016).Altered structural connectome in adolescent socially isolated mice.NEUROIMAGE,139,259-270.
MLA Liu, Cirong,et al."Altered structural connectome in adolescent socially isolated mice".NEUROIMAGE 139(2016):259-270.
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