CASIA OpenIR  > 中国科学院分子影像重点实验室
Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers
Feng, Dan1,2; Yuan, Kai1,2; Li, Yangding1,2; Cai, Chenxi1,2; Yin, Junsen1,2; Bi, Yanzhi1,2; Cheng, Jiadong1,2; Guan, Yanyan1,2; Shi, Sha1,2; Yu, Dahua3; Jin, Chenwang4; Lu, Xiaoqi3; Qin, Wei1,2; Tian, Jie1,2,5
Source PublicationBRAIN IMAGING AND BEHAVIOR
2016-06-01
Volume10Issue:2Pages:506-516
SubtypeArticle
AbstractTobacco use during later adolescence and young adulthood may cause serious neurophysiological changes; rationally, it is extremely important to study the relationship between brain dysfunction and behavioral performances in young adult smokers. Previous resting state studies investigated the neural mechanisms in smokers. Unfortunately, few studies focused on spontaneous activity differences between young adult smokers and nonsmokers from both intra-regional and inter-regional levels, less is known about the association between resting state abnormalities and behavioral deficits. Therefore, we used fractional amplitude of low frequency fluctuation (fALFF) and resting state functional connectivity (RSFC) to investigate the resting state spontaneous activity differences between young adult smokers and nonsmokers. A correlation analysis was carried out to assess the relationship between neuroimaging findings and clinical information (pack-years, cigarette dependence, age of onset and craving score) as well as cognitive control deficits measured by the Stroop task. Consistent with previous addiction findings, our results revealed the resting state abnormalities within frontostriatal circuits, i.e., enhanced spontaneous activity of the caudate and reduced functional strength between the caudate and anterior cingulate cortex (ACC) in young adult smokers. Moreover, the fALFF values of the caudate were correlated with craving and RSFC strength between the caudate and ACC was associated with the cognitive control impairments in young adult smokers. Our findings could lead to a better understanding of intrinsic functional architecture of baseline brain activity in young smokers by providing regional and brain circuit spontaneous neuronal activity properties as well as their association with cognitive control impairments.
KeywordYoung Adult Smokers Fractional Amplitude Of Low Frequency Fluctuation Resting State Functional Connectivity Cognitive Control Caudate Anterior Cingulate Cortex
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-015-9427-z
WOS KeywordINTELLIGENCE SCALE-4TH EDITION ; ANTERIOR CINGULATE CORTEX ; RESTING-STATE FMRI ; CIGARETTE-SMOKING ; DOPAMINE RELEASE ; NICOTINE-DEPENDENCE ; INHIBITORY CONTROL ; ADDICTION ; BRAIN ; CONNECTIVITY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000382390000017
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/12646
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Inner Mongolia Key Lab Pattern Recognit & Intelli, Sch Informat Engn, Baotou 014010, Inner Mongolia, Peoples R China
4.Xi An Jiao Tong Univ, Dept Med Imaging, Affiliated Hosp 1, Coll Med, Xian 710061, Shaanxi, Peoples R China
5.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Feng, Dan,Yuan, Kai,Li, Yangding,et al. Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers[J]. BRAIN IMAGING AND BEHAVIOR,2016,10(2):506-516.
APA Feng, Dan.,Yuan, Kai.,Li, Yangding.,Cai, Chenxi.,Yin, Junsen.,...&Tian, Jie.(2016).Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers.BRAIN IMAGING AND BEHAVIOR,10(2),506-516.
MLA Feng, Dan,et al."Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers".BRAIN IMAGING AND BEHAVIOR 10.2(2016):506-516.
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