CASIA OpenIR  > 脑网络组研究中心
Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment
Yang, Shi-Qi1; Xu, Zhi-Peng2,3,4; Xiong, Ying1; Zhan, Ya-Feng5,6; Guo, Lin-Ying1; Zhang, Shun1; Jiang, Ri-Feng1; Yao, Yi-Hao1; Qin, Yuan-Yuan1; Wang, Jian-Zhi2,3; Liu, Yong6,7; Zhu, Wen-Zhen1
2016-09-13
发表期刊SCIENTIFIC REPORTS
卷号6
文章类型Article
摘要Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment. We investigated whether alterations of intranetwork and internetwork functional connectivity with T2DM progression exist, by using resting-state functional MRI. MRI data were analysed from 19 T2DM patients with normal cognition (DMCN) and 19 T2DM patients with cognitive impairment (DMCI), 19 healthy controls (HC). Functional connectivity among 36 previously well-defined brain regions which consisted of 5 resting-state network (RSN) systems [default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL) and sensorimotor network (SMN)] was investigated at 3 levels (integrity, network and connectivity). Impaired intranetwork and internetwork connectivity were found in T2DM, especially in DMCI, on the basis of the three levels of analysis. The bilateral posterior cerebellum, the right insula, the DMN and the CON were mainly involved in these changes. The functional connectivity strength of specific brain architectures in T2DM was found to be associated with haemoglobin A1c (HbA1c), cognitive score and illness duration. These network alterations in intergroup differences, which were associated with brain functional impairment due to T2DM, indicate that network organizations might be potential biomarkers for predicting the clinical progression, evaluating the cognitive impairment, and further understanding the pathophysiology of T2DM.
WOS标题词Science & Technology
DOI10.1038/srep32980
关键词[WOS]RESTING-STATE ; ALZHEIMERS-DISEASE ; BRAIN NETWORKS ; INSULIN-RESISTANCE ; SALIENCE NETWORK ; ACTIVATION ; CLASSIFICATION ; COMPLICATIONS ; METAANALYSIS ; INFORMATION
收录类别SCI
语种英语
项目资助者National Program of the Ministry of Science and Technology of China during the "12th Five-year Plan"(2011BAI08B10) ; National Natural Science Foundation of China (NSFC)(81171308 ; Youth Innovation Promotion Association CAS(2014119) ; Natural Science Foundation of Beijing(7152096) ; Beijing Nova Program(Z1511000003150112) ; Ministry of Science and Technology of China(2013DFG32670) ; 81570462 ; 81571062 ; 81270020)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000382917400002
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12654
专题脑网络组研究中心
作者单位1.Huazhong Univ Sci & Technol, Tongji Hosp, Dept Radiol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathophysiol, Wuhan 430030, Hubei, Peoples R China
3.Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Brain Sci, Key Lab Neurol Dis, Educ Minist China,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
4.Wuhan Gen Hosp Guangzhou Command, Dept Neurol, Wuhan 430070, Hubei, Peoples R China
5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China
6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
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Yang, Shi-Qi,Xu, Zhi-Peng,Xiong, Ying,et al. Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment[J]. SCIENTIFIC REPORTS,2016,6.
APA Yang, Shi-Qi.,Xu, Zhi-Peng.,Xiong, Ying.,Zhan, Ya-Feng.,Guo, Lin-Ying.,...&Zhu, Wen-Zhen.(2016).Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment.SCIENTIFIC REPORTS,6.
MLA Yang, Shi-Qi,et al."Altered Intranetwork and Internetwork Functional Connectivity in Type 2 Diabetes Mellitus With and Without Cognitive Impairment".SCIENTIFIC REPORTS 6(2016).
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