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Aberrant Arcuate Fasciculus in Schizophrenia with Auditory Verbal Hallucination: A Multi-site Study
Xie, Sangma1,2; Wang, Jiaojian3; Tao, Yan1,2; Fan, Lingzhong1,2; Liu, Bing1,2; Song, Ming1,2; Jiang, Tianzi1,2,3,4,5
Conference Name22th Annual Meeting of the Organization for Human Brain Mapping
Source Publication国际会议
Conference Date20160626-20160630
Conference PlaceGeneva, Switzerland
Auditory verbal hallucination (AVH) is one of the most potentially debilitating symptoms of schizophrenia [1, 2]. Recent DTI studies have proposed that the AVH is associated with altered integrity of the arcuate fasciculus (AF) [3-6]. However, there is considerable heterogeneity in the patterns of abnormal integrity of AF across studies. These inconsistent results might in part be explained by the relatively small sample size. Inspired by the studies using functional MRI [8], we hypothesis that increased fractional anisotropy (FA) of the AF would be observed in the schizophrenia with AVHs. This study aimed to investigate the alterations of perisylvian language pathways using a relatively large sample collected from 4 sites and examine its reproducibility.
A total of 209 schizophrenia patients (113 AVH and 96 nAVH) and 269 healthy controls (HC) were recruited from 4 independent sites. Detailed demographic and clinical data were located in Figure 1. The main acquisition parameters included: field-of-view = 256 mm * 256 mm, matrix size = 128 * 128, slices = 50, voxel size = 2 mm * 2 mm * 3 mm. For each subject, 1 b0 volume and 64 diffsusion-weighted (b = 1000 s/mm2) volumes were acquired. FA maps were estimated using FSL FDT tool. The atlas of perisylvian language pathways used was created by Catani et al [9]. We used linear and nonlinear registration methods to register the three segments to individual DTI space. Median FA value of each segment was computed. The statistical analysis was performed in SPSS. Independent ANCOVAs were performed to characterize the group differences of each segment. We used post hoc two sample Student t tests to evaluate the differences of each segment between every two groups. In the meta-analysis, we pooled each site’s Cohen’s d group effect size using an inverse variance-weighted random-effects model as implemented in the R package metafor. Age and gender were entered as covariates of no interest. In addition, site was defined as a covariate in the combination analysis.
In the analyses of combined dataset, a significant group difference in FA of the long segment was observed (F = 5.786, P < 0.01, Bonferroni-corrected). Follow-up post hoc analyses revealed a significant increase of FA in the long segment in the AVH group compared to the HC group (Figure 2). The nAVH group showed intermediate FA value of this segment, and did not differ significantly from either group. There were no significant between-group differences in the anterior and posterior segments. Independent ANCOVAs of FA measurements of each segment revealed a significant group difference in the long segment for PKU6 site (F = 3.352, P = 0.037, uncorrected). Post hoc analyses indicated significant higher FA value in the long segment in the AVH group compared to the HC group (Figure 3). No significant group differences were observed in the other three sites. The long segment showed replicated change trend of FA in all 4 sites (HC < nAVH < AVH, Figure 3). In the meta-analysis, AVH group showed significantly higher FA in the long segment compared to HC (Figure 4).
In conclusion, the AVH group relative to the control group expressed excessive integrity of the long segment within the perisylvian language network, and the changing trajectory of the FA in the long segment was consistent across the 4 sites. These findings not only provide reliable support to the hypothesis that structural hyperconnectivity between Wernicke’s region and Broca’s region may represent a neuroanatomical signature in AVH of schizophrenia, but also to the pathophysiological model of AVH based on a potential failure in recognizing inner speech.
KeywordDiffusion Mri Schizophrenia Auditory Verbal Hallucination
Document Type会议论文
Corresponding AuthorJiang, Tianzi
Affiliation1.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
2.National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
3.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
4.Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia
5.CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
Recommended Citation
GB/T 7714
Xie, Sangma,Wang, Jiaojian,Tao, Yan,et al. Aberrant Arcuate Fasciculus in Schizophrenia with Auditory Verbal Hallucination: A Multi-site Study[C],2016.
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