Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease

doi:10.1109/JSTSP.2016.2600298

	Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease
	Zhan, Yafeng 1,2,3; Yao, Hongxiang 4; Wang, Pan5 ; Zhou, Bo5 ; Zhang, Zengqiang 5; Guo, Yan'e 5; An, Ningyu 4; Ma, Jianhua 1; Zhang, Xi 5; Liu, Yong2,3 ; Liu Yong
发表期刊	IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
	2016-10-01
卷号	10 期号:7 页码:1182-1188
文章类型	Article
摘要	Alzheimer's disease (AD) and mild cognitive impairment (MCI) have been associated with impaired communication among large-scale brain networks. Given nature that interconnected subnetworks are responsible for daily behavior than a single pair of functional connectivity, it is valid to use a network-based statistic (NBS) method to exploit the clustering structure of connectivity alterations in AD/MCI. We explored abnormal network components using NBS based on resting-state functional magnetic resonance imaging (fMRI) connectivity in a sample of patients with AD (N = 35), MCI (N = 27) and age-matched healthy subjects (N = 27). The results demonstrated that patients had reduced functional connectivity strength in several components, including the default mode network, sensorimotor network, visual-sensory network, and visual-attention network. In patients with AD, the functional connectivity of these components of interest (COIs) exhibited greater attenuation than that in MCI subjects compared with normal cognition. A greater degree of cognitive impairment was correlated with a greater decrease in functional connectivity in the identified COIs. These results indicate that the neurodegenerative disruption of fMRI connectivity is widely distributed in several networks in AD/MCI. These profiles deepen our understanding of the neural basis of AD/MCI dysfunction and indicate the potential of resting-state fMRI measures as biomarkers or predictors of AD.
关键词	Alzheimer's Disease Components Of Interest Mild Cognitive Impairment Network-based Statistic
WOS标题词	Science & Technology ; Technology
DOI	10.1109/JSTSP.2016.2600298
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; DEFAULT-MODE NETWORK ; RESTING-STATE FMRI ; VENTRAL ATTENTION SYSTEMS ; HUMAN BRAIN ; DISCONNECTION SYNDROME ; MRI ; MEMORY ; DISEASE,ALZHEIMERS ; DORSAL
收录类别	SCI ; SSCI
语种	英语
项目资助者	National Natural Science Foundation of China(81571062 ; Youth Innovation Promotion Association CAS(2014119) ; Natural Science Foundation of Beijing(7152096) ; Beijing Nova Program(Z1511000003150112) ; National Laboratory of Pattern Recognition(201407344) ; 81471120 ; 61431012)
WOS研究方向	Engineering
WOS类目	Engineering, Electrical & Electronic
WOS记录号	WOS:000385576200006
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/13199
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Liu Yong
作者单位	1.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhan, Yafeng,Yao, Hongxiang,Wang, Pan,et al. Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease[J]. IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING,2016,10(7):1182-1188.
APA	Zhan, Yafeng.,Yao, Hongxiang.,Wang, Pan.,Zhou, Bo.,Zhang, Zengqiang.,...&Liu Yong.(2016).Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease.IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING,10(7),1182-1188.
MLA	Zhan, Yafeng,et al."Network-Based Statistic Show Aberrant Functional Connectivity in Alzheimer's Disease".IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING 10.7(2016):1182-1188.

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