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Distinct resting-state brain activity in patients with functional constipation
Zhu, Qiang1; Cai, Weiwei1; Zheng, Jianyong2; Li, Guanya1; Meng, Qianqian1; Liu, Qiaoyun2; Zhao, Jizheng3; von Deneen, Karen M.1; Wang, Yuanyuan1; Cui, Guangbin4; Duan, Shijun4; Han, Yu4; Wang, Huaning5; Tian, Jie1,6; Zhang, Yi1; Nie, Yongzhan2
AbstractFunctional constipation (FC) is a common functional gastrointestinal disorder (FGID) with a higher prevalence in clinical practice. The primary brain regions involved in emotional arousal regulation, somatic, sensory and motor control processing have been identified with neuroimaging in FGID. It remains unclear how these factors interact to influence the baseline brain activity of patients with FC. In the current study, we combined resting-state fMRI (RS-fMRI) with Granger causality analysis (GCA) to investigate the causal interactions of the brain areas in 14 patients with FC and in 26 healthy controls (HC). Our data showed significant differences in baseline brain activities in a number of major brain regions implicated in emotional process modulation (i.e. dorsal anterior cingulate cortex-dACC, anterior insula-aINS, orbitofrontal cortex-OFC, hippocampus-HIPP), somatic and sensory processing, and motor control (i.e., supplementary motor area-SMA, precentral gyrus-PreCen) (P< 0.05, FDR correction). The GCA results revealed stronger effective connectivity from the OFC and dACC, which are regions involved with emotional regulation, propel limbic regions at the aINS and HIPP to induce abnormal emotional processing regulating visceral responses; and weaker effective connectivity from the SMA and PreCen, which are regions involved with somatic, sensory and motor control, propel the aINS and HIPP, suggesting abnormalities of sensory and behavioral responses. Such information of basal level functional abnormalities expands our current understanding of neural mechanisms underlying functional constipation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KeywordFunctional Constipation Fmri Granger Causality Resting-state Emotional Arousal Somatic And Sensory
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(81470816 ; Shaanxi Provincial Natural Science Foundation(2015JM3117) ; 81271549 ; 61131003 ; 61431013 ; 81201081 ; 81227901 ; 81120108005 ; 81501543 ; 81371530 ; 81571751 ; 81571753)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000385320900023
Citation statistics
Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Ctr Brain Imaging, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Gastrointestinal Hosp, 127 Changle West Rd, Xian 710032, Shaanxi, Peoples R China
3.Northwest A&F Univ, Coll Mech & Elect Engn, Yangling 712100, Shaanxi, Peoples R China
4.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, Xian 710038, Shaanxi, Peoples R China
5.Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian 710032, Shaanxi, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Qiang,Cai, Weiwei,Zheng, Jianyong,et al. Distinct resting-state brain activity in patients with functional constipation[J]. NEUROSCIENCE LETTERS,2016,632:141-146.
APA Zhu, Qiang.,Cai, Weiwei.,Zheng, Jianyong.,Li, Guanya.,Meng, Qianqian.,...&Nie, Yongzhan.(2016).Distinct resting-state brain activity in patients with functional constipation.NEUROSCIENCE LETTERS,632,141-146.
MLA Zhu, Qiang,et al."Distinct resting-state brain activity in patients with functional constipation".NEUROSCIENCE LETTERS 632(2016):141-146.
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