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Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults
Xu, Jiayuan1,2; Qin, Wen1,2; Liu, Bing3,4; Jiang, Tianzi3,4; Yu, Chunshui1,2
Source PublicationBRAIN STRUCTURE & FUNCTION
2016-11-01
Volume221Issue:8Pages:3891-3901
SubtypeArticle
AbstractDifferent genotypic combinations of COMT and DRD2 can generate multiple subgroups with different levels of dopamine signaling. Its modulations on brain properties can be investigated by analyzing the combined gene effects of COMT and DRD2. However, the inherent association between modulation patterns of the dopamine system on structural and functional properties of the brain remains unknown. In 294 healthy young adults, we investigated both additive and non-additive interactions of COMT and DRD2 on gray matter volume (GMV) and resting-state functional connectivity (rsFC) using a voxel-based analysis. We found a significant non-additive COMT x DRD2 interaction in the right dorsal anterior cingulate cortex (dACC), exhibiting an inverted U-shape modulation by dopamine signaling. We also found a significant non-additive COMT x DRD2 interaction in the rsFC between the right dACC and precuneus, displaying a U-shape modulation by dopamine signaling. Moreover, this rsFC was negatively correlated with the GMV of the right dACC. Although the additive interaction did not pass corrections for multiple comparisons, we also found a trend towards an inverse modulation pattern and a negative correlation between the GMV and rsFC of the right inferior frontal gyrus. No genotypic differences were detected in any assessments of the cognition, mood and personality. These findings suggest that healthy young adults without optimal dopamine signaling may maintain their normal behavioral performance via a functional compensatory mechanism in response to structural deficit due to genetic variation.
KeywordCatechol-o-methyltransferase Dopamine D2 Receptor Functional Magnetic Resonance Imaging Gray Matter Volume Resting-state Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s00429-015-1134-4
WOS KeywordANTERIOR CINGULATE CORTEX ; VAL(108/158) MET GENOTYPE ; O-METHYLTRANSFERASE COMT ; D2 RECEPTOR GENE ; WORKING-MEMORY ; VAL158MET POLYMORPHISM ; EXECUTIVE CONTROL ; INSULAR CORTEX ; SCHIZOPHRENIA ; EXPRESSION
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 program)(2011CB707800) ; Natural Science Foundation of China(81425013 ; Chinese Academy of Sciences(XDB02030300) ; 81271551 ; 91132301 ; 81301201)
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000386352500003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13328
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, 154 Anshan Rd, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jiayuan,Qin, Wen,Liu, Bing,et al. Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults[J]. BRAIN STRUCTURE & FUNCTION,2016,221(8):3891-3901.
APA Xu, Jiayuan,Qin, Wen,Liu, Bing,Jiang, Tianzi,&Yu, Chunshui.(2016).Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults.BRAIN STRUCTURE & FUNCTION,221(8),3891-3901.
MLA Xu, Jiayuan,et al."Interactions of genetic variants reveal inverse modulation patterns of dopamine system on brain gray matter volume and resting-state functional connectivity in healthy young adults".BRAIN STRUCTURE & FUNCTION 221.8(2016):3891-3901.
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