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Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults
Shen, Junlin1; Zhang, Peng1; Liu, Huaigui1; Xu, Lixue1; Xu, Jiayuan1; Qin, Wen1; Liu, Bing2; Jiang, Tianzi2; Yu, Chunshui1
2016-11-01
发表期刊BRAIN STRUCTURE & FUNCTION
卷号221期号:8页码:4103-4110
文章类型Article
摘要The sortilin-related receptor 1 (SORL1) gene has been associated with late-onset Alzheimer's disease (LOAD) and structural impairments in several ethnic populations. However, how this gene affects brain function properties remains unclear. We investigated associations of SORL1 rs2070045 with functional connectivity density (FCD) in healthy young adults. This single-nucleotide polymorphism was selected because it is the SORL1 variant that has been frequently associated with LOAD in several populations, including the Chinese Han population. A total of 275 healthy young Chinese Han subjects with successful genotyping and MRI examinations were included. The effect of SORL1 rs2070045 was explored using a voxel-wise FCD analysis. A significant effect of SORL1 rs2070045 on the FCD was found in the right inferior temporal gyrus. The risk G allele carriers of the rs2070045 exhibited a lower FCD than the protective TT carriers. This effect was independent of the status of apolipoprotein E. This study provides the first evidence that the SORL1 gene is associated with brain FCD differences in healthy young adults. In the genetic risk subjects, connectivity impairment already starts during young adulthood, which may predispose the risk allele carriers to be susceptible to LOAD after several decades.
关键词Fmri Sorl1 Snps Linkage Disequilibrium Neuroimaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s00429-015-1149-x
关键词[WOS]ONSET ALZHEIMERS-DISEASE ; MILD COGNITIVE IMPAIRMENT ; HAN CHINESE POPULATION ; RS2070045 POLYMORPHISM ; JAPANESE POPULATION ; APOE GENOTYPE ; GENOME-WIDE ; HUMAN BRAIN ; ASSOCIATION ; RISK
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81425013 ; 81301202 ; 81301201 ; 91332113 ; 81271551)
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
WOS类目Anatomy & Morphology ; Neurosciences
WOS记录号WOS:000386352500016
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13334
专题脑网络组研究中心
作者单位1.Tianjin Med Univ Gen Hosp, Dept Radiol, 154 Anshan Rd, Tianjin 300052, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
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Shen, Junlin,Zhang, Peng,Liu, Huaigui,et al. Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults[J]. BRAIN STRUCTURE & FUNCTION,2016,221(8):4103-4110.
APA Shen, Junlin.,Zhang, Peng.,Liu, Huaigui.,Xu, Lixue.,Xu, Jiayuan.,...&Yu, Chunshui.(2016).Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults.BRAIN STRUCTURE & FUNCTION,221(8),4103-4110.
MLA Shen, Junlin,et al."Modulation effect of the SORL1 gene on functional connectivity density in healthy young adults".BRAIN STRUCTURE & FUNCTION 221.8(2016):4103-4110.
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