CASIA OpenIR  > 中国科学院分子影像重点实验室
Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy
Li, Hao1; Zhou, Jian1; Chi, Chongwei2; Mao, Yamin2; Yang, Fan1; Tian, Jie2; Wang, Jun1
Source PublicationJOURNAL OF THORACIC DISEASE
2016-07-01
Volume8Issue:7Pages:1841-1845
SubtypeArticle
AbstractFailure to identify all the possible bullous lesions was considered an important reason for the higher recurrence rate after the VATS bullectomy. We applied the latest near-infrared (NIR) thoracoscope with indocyanine green (ICG) to detect bullous lesions for patients with spontaneous pneumothorax. Two male patients with spontaneous pneumothorax and poorly identified bullae intraoperatively were included in this pilot study. An NIR thoracoscope with two different doses of ICG injection (0.2 and 0.6 mg/kg) was used to detect bullous lesions during VATS bullectomy. Partial lung resections of the bullous lesions were performed under syncretic mode. Data was managed with ImageJ software. No procedure-related complications were observed. The fluorescent signal was detected in normal lung tissue 10.5 seconds (mean, 10-11 seconds) after the ICG bolus, and lasted up to 525 seconds (mean, 480-570 seconds). The bullous lesions showed an obviously decreased fluorescent densities comparing to adjacent normal tissue. At the dosage of 0.6 mg/kg, ICG emits sufficient fluorescence to demonstrate the precise border of bullae, with the max SBR of 6.32. All resected specimens were confirmed as bullous lesions microscopically. NIR thoracoscope with intravenous ICG is a safe, accurate and real-time method to detect bullous lesions of lung tissue difficult to be found under normal light in human subjects.
KeywordThoracoscopy/vats Emphysema/bullae Pneumothorax
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.21037/jtd.2016.06.02
WOS KeywordSURGERY ; LUNG
Indexed BySCI
Language英语
Funding OrganizationPeking University People's Hospital Research and Development Foundation(RDC2015-33)
WOS Research AreaRespiratory System
WOS SubjectRespiratory System
WOS IDWOS:000385021800115
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13339
Collection中国科学院分子影像重点实验室
Affiliation1.Peking Univ, Peoples Hosp, Ctr Thorac Miniinvas Surg, Dept Thorac Surg, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Li, Hao,Zhou, Jian,Chi, Chongwei,et al. Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy[J]. JOURNAL OF THORACIC DISEASE,2016,8(7):1841-1845.
APA Li, Hao.,Zhou, Jian.,Chi, Chongwei.,Mao, Yamin.,Yang, Fan.,...&Wang, Jun.(2016).Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy.JOURNAL OF THORACIC DISEASE,8(7),1841-1845.
MLA Li, Hao,et al."Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy".JOURNAL OF THORACIC DISEASE 8.7(2016):1841-1845.
Files in This Item: Download All
File Name/Size DocType Version Access License
jtd-08-07-1841.pdf(1330KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Hao]'s Articles
[Zhou, Jian]'s Articles
[Chi, Chongwei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Hao]'s Articles
[Zhou, Jian]'s Articles
[Chi, Chongwei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Hao]'s Articles
[Zhou, Jian]'s Articles
[Chi, Chongwei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: jtd-08-07-1841.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.