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Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy
Li, Hao1; Zhou, Jian1; Chi, Chongwei2; Mao, Yamin2; Yang, Fan1; Tian, Jie2; Wang, Jun1
2016-07-01
发表期刊JOURNAL OF THORACIC DISEASE
卷号8期号:7页码:1841-1845
文章类型Article
摘要Failure to identify all the possible bullous lesions was considered an important reason for the higher recurrence rate after the VATS bullectomy. We applied the latest near-infrared (NIR) thoracoscope with indocyanine green (ICG) to detect bullous lesions for patients with spontaneous pneumothorax. Two male patients with spontaneous pneumothorax and poorly identified bullae intraoperatively were included in this pilot study. An NIR thoracoscope with two different doses of ICG injection (0.2 and 0.6 mg/kg) was used to detect bullous lesions during VATS bullectomy. Partial lung resections of the bullous lesions were performed under syncretic mode. Data was managed with ImageJ software. No procedure-related complications were observed. The fluorescent signal was detected in normal lung tissue 10.5 seconds (mean, 10-11 seconds) after the ICG bolus, and lasted up to 525 seconds (mean, 480-570 seconds). The bullous lesions showed an obviously decreased fluorescent densities comparing to adjacent normal tissue. At the dosage of 0.6 mg/kg, ICG emits sufficient fluorescence to demonstrate the precise border of bullae, with the max SBR of 6.32. All resected specimens were confirmed as bullous lesions microscopically. NIR thoracoscope with intravenous ICG is a safe, accurate and real-time method to detect bullous lesions of lung tissue difficult to be found under normal light in human subjects.
关键词Thoracoscopy/vats Emphysema/bullae Pneumothorax
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.21037/jtd.2016.06.02
关键词[WOS]SURGERY ; LUNG
收录类别SCI
语种英语
项目资助者Peking University People's Hospital Research and Development Foundation(RDC2015-33)
WOS研究方向Respiratory System
WOS类目Respiratory System
WOS记录号WOS:000385021800115
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13339
专题中国科学院分子影像重点实验室
作者单位1.Peking Univ, Peoples Hosp, Ctr Thorac Miniinvas Surg, Dept Thorac Surg, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100044, Peoples R China
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Li, Hao,Zhou, Jian,Chi, Chongwei,et al. Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy[J]. JOURNAL OF THORACIC DISEASE,2016,8(7):1841-1845.
APA Li, Hao.,Zhou, Jian.,Chi, Chongwei.,Mao, Yamin.,Yang, Fan.,...&Wang, Jun.(2016).Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy.JOURNAL OF THORACIC DISEASE,8(7),1841-1845.
MLA Li, Hao,et al."Clinical application of near-infrared thoracoscope with indocyanine green in video-assisted thoracoscopic bullectomy".JOURNAL OF THORACIC DISEASE 8.7(2016):1841-1845.
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