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Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle
Zeng, Chaoting1,2; Shang, Wenting1,3; Liang, Xiaoyuan1,2; Liang, Xiao1,3; Chen, Qingshan1,2; Chi, Chongwei1,3; Du, Yang1,3; Fang, Chihua2; Tian, Jie1,3
2016-11-02
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号8期号:43页码:29232-29241
文章类型Article
摘要To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near infrared (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision. The nanoparticles (NPs) exhibited good monodispersity, fluorescence stability, biocompatibility, and NIR/CT signaling and had a preferable temperature response under MR laser irradiation in vitro or in vivo. Using a combination of NIR/CT imaging and PTT treatment, the tumor could be accurately positioned and thoroughly eradicated in vivo by Au@MSNs-ICG injection. Hence, the multifunctional NPs could play an important role in facilitating the accurate treatment of tumors in future clinical applications.
关键词Gold Nanospheres Indocyanine Green Computed Tomography Nir Fluorescence Imaging Photothermal Therapy Imaging-guided Therapy
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.6b06883
关键词[WOS]RAY-COMPUTED-TOMOGRAPHY ; TARGETED GOLD NANOPARTICLES ; NEGATIVE BREAST-CANCER ; LARGE-SCALE SYNTHESIS ; INDOCYANINE-GREEN ; IN-VIVO ; CONTRAST AGENTS ; MESOPOROUS SILICA ; MAGNETIC-RESONANCE ; LUNG-CANCER
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81227901 ; National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; Guangdong provincial science and technology plan projects(2014A020212647) ; Cultivation of Guangdong College Students' Scientific and Technological Innovation project ("Climbing Program" Special Funds)(pdjh2016b0103 ; 81501540 ; pdjh2016a0090) ; 61231004 ; U1401254 ; 61401462 ; 61501462 ; 81527805 ; 81470083)
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000387095300007
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13342
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, 253 Gongye Ave, Guangzhou 510280, Guangdong, Peoples R China
3.Beijing Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
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GB/T 7714
Zeng, Chaoting,Shang, Wenting,Liang, Xiaoyuan,et al. Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(43):29232-29241.
APA Zeng, Chaoting.,Shang, Wenting.,Liang, Xiaoyuan.,Liang, Xiao.,Chen, Qingshan.,...&Tian, Jie.(2016).Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle.ACS APPLIED MATERIALS & INTERFACES,8(43),29232-29241.
MLA Zeng, Chaoting,et al."Cancer Diagnosis and Imaging-Guided Photothermal Therapy Using a Dual-Modality Nanoparticle".ACS APPLIED MATERIALS & INTERFACES 8.43(2016):29232-29241.
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