CASIA OpenIR  > 中国科学院分子影像重点实验室
Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging
Liang, Xiaoyuan1,2,3; Shang, Wenting2,3; Chi, Chongwei2,3; Zeng, Chaoting1; Wang, Kun2,3; Fang, Chihua1; Chen, Qingshan1; Liu, Huiyu4; Fan, Yingfang1; Tian, Jie2,3
Source PublicationCANCER LETTERS
2016-12-28
Volume383Issue:2Pages:243-249
SubtypeArticle
AbstractRecently, photothermal therapy (PTT) has become viewed as an ideal auxiliary therapeutic treatment for cancers. However, the development of safe, convenient, and highly effective photothermal agents remains a great challenge. In this study, we prepared single-walled carbon nanotubes (SWNTs) for PIT against breast tumors under the guidance of infrared fluorescent cyanines. Tumors were accurately located using near-infrared imaging (NIR) and then exposed to laser irradiation. Both the in vivo and in vitro results showed that the SWNTs have high stability and low cytotoxicity. Introducing polyethylene glycol into our nanoparticles increased the blood-circulation time. Our in vivo results further showed that Cy5.5-conjugated SWNTs mediated PTT, resulting in efficient tumor suppression in mice under the guidance of near-infrared imaging. Due to the small amount of absorption at 808-nm, Cy5.5 increased the efficiency of PTE Breast tumors significantly shrunk after irradiation under the 808-nm near-infrared laser. The treated mice developed scabs, but otherwise recovered after 15 days, and their physical conditions restored gradually. These data indicate that our unique photothermal-responsive SWNT-Cy5.5-based theranostic agent can serve as a promising candidate for PTT. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KeywordPhotothermal Therapy (Ptt) Near-infrared Imaging (Nir) Single-walled Carbon Nanotubes Cy5.5
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.canlet.2016.09.006
WOS KeywordCANCER-THERAPY ; FUNCTIONAL NANOMATERIALS ; GOLD NANOPARTICLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; CELLS ; NANOSTRUCTURES ; NANOMEDICINE ; THERANOSTICS ; HYPERTHERMIA
Indexed BySCI
Language英语
Funding OrganizationNational High Technology Research and Development Program of China (863 Program)(2012AA021105) ; National Natural Science Foundation of China(81501540 ; Natural Science Foundation of China-Guangdong United Funds(U1401254) ; Science and Technology Planning Project of Guangdong Province, China(2015B031800091) ; Guangdong Province Science and Technology Plan Project(2016A020220013) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; 61501462)
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000388052900011
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13343
Collection中国科学院分子影像重点实验室
Affiliation1.Southern Med Univ, Zhujiang Hosp, Dept Heparobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liang, Xiaoyuan,Shang, Wenting,Chi, Chongwei,et al. Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging[J]. CANCER LETTERS,2016,383(2):243-249.
APA Liang, Xiaoyuan.,Shang, Wenting.,Chi, Chongwei.,Zeng, Chaoting.,Wang, Kun.,...&Tian, Jie.(2016).Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging.CANCER LETTERS,383(2),243-249.
MLA Liang, Xiaoyuan,et al."Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging".CANCER LETTERS 383.2(2016):243-249.
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