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Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging
Liang, Xiaoyuan1,2,3; Shang, Wenting2,3; Chi, Chongwei2,3; Zeng, Chaoting1; Wang, Kun2,3; Fang, Chihua1; Chen, Qingshan1; Liu, Huiyu4; Fan, Yingfang1; Tian, Jie2,3
2016-12-28
发表期刊CANCER LETTERS
卷号383期号:2页码:243-249
文章类型Article
摘要Recently, photothermal therapy (PTT) has become viewed as an ideal auxiliary therapeutic treatment for cancers. However, the development of safe, convenient, and highly effective photothermal agents remains a great challenge. In this study, we prepared single-walled carbon nanotubes (SWNTs) for PIT against breast tumors under the guidance of infrared fluorescent cyanines. Tumors were accurately located using near-infrared imaging (NIR) and then exposed to laser irradiation. Both the in vivo and in vitro results showed that the SWNTs have high stability and low cytotoxicity. Introducing polyethylene glycol into our nanoparticles increased the blood-circulation time. Our in vivo results further showed that Cy5.5-conjugated SWNTs mediated PTT, resulting in efficient tumor suppression in mice under the guidance of near-infrared imaging. Due to the small amount of absorption at 808-nm, Cy5.5 increased the efficiency of PTE Breast tumors significantly shrunk after irradiation under the 808-nm near-infrared laser. The treated mice developed scabs, but otherwise recovered after 15 days, and their physical conditions restored gradually. These data indicate that our unique photothermal-responsive SWNT-Cy5.5-based theranostic agent can serve as a promising candidate for PTT. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
关键词Photothermal Therapy (Ptt) Near-infrared Imaging (Nir) Single-walled Carbon Nanotubes Cy5.5
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.canlet.2016.09.006
关键词[WOS]CANCER-THERAPY ; FUNCTIONAL NANOMATERIALS ; GOLD NANOPARTICLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; CELLS ; NANOSTRUCTURES ; NANOMEDICINE ; THERANOSTICS ; HYPERTHERMIA
收录类别SCI
语种英语
项目资助者National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; National Natural Science Foundation of China(81501540 ; Natural Science Foundation of China-Guangdong United Funds(U1401254) ; Science and Technology Planning Project of Guangdong Province, China(2015B031800091) ; Guangdong Province Science and Technology Plan Project(2016A020220013) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; 61501462)
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000388052900011
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13343
专题中国科学院分子影像重点实验室
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Heparobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China
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Liang, Xiaoyuan,Shang, Wenting,Chi, Chongwei,et al. Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging[J]. CANCER LETTERS,2016,383(2):243-249.
APA Liang, Xiaoyuan.,Shang, Wenting.,Chi, Chongwei.,Zeng, Chaoting.,Wang, Kun.,...&Tian, Jie.(2016).Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging.CANCER LETTERS,383(2),243-249.
MLA Liang, Xiaoyuan,et al."Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging".CANCER LETTERS 383.2(2016):243-249.
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