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Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals
He, Kunshan; Chi, Chongwei; Kou, Deqiang; Huang, Wenhe; Wu, Jundong; Wang, Yabing; He, Lifang; Ye, Jinzuo; Mao, Yamin; Zhang, Guo-Jun; Wang, Jiandong; Tian, Jie
2016-12-01
发表期刊TRANSLATIONAL RESEARCH
期号178页码:74-80
文章类型Article
摘要Sentinel lymph node biopsy (SLNB) has become a standard of care to detect axillary lymph metastasis in early-stage breast cancer patients with clinically negative axillary lymph nodes. Current SLNB detection modalities comprising a blue dye, a radioactive tracer, or a combination of both have advantages as well as disadvantages. Thus, near-infrared fluorescence imaging using indocyanine green (ICG) has recently been regarded as a novel method that has generated interest for SLNB around the world. However, the lack of appropriate fluorescence imaging systems has hindered further research and wide application of this method. Therefore, we developed novel fluorescence image-guided resection equipment (FIRE) to detect sentinel lymph nodes (SLNs). Moreover, to compare the ICG fluorescence imaging method with the blue dye method and to explore the universal feasibility of the former, a different type of hospital study was conducted. Ninety-nine eligible patients participated in the study at 3 different types of hospitals. After subcutaneous ICG allergy testing, all the patients were subcutaneously injected with methylene blue and ICG into the subareolar area. Consequently, 276 SLNs (range 1-7) were identified in 98 subjects (detection rate: 99%) by using the ICG fluorescence imaging method. In contrast, the blue dye method only identified 202 SLNs (range 1-7) in 91 subjects (detection rate: 91.92%). Besides, the results of the fluorescence imaging method were similar in the 3 hospitals. Our findings indicate the universal feasibility of the ICG fluorescence imaging method for SLNB using the fluorescence image-guided resection equipment in early breast cancer detection.
关键词Indocyanine Green Fluorescence
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.trs1.2016.07.010
关键词[WOS]BREAST-CANCER PATIENTS ; SURGERY ; TRIAL ; IDENTIFICATION ; NAVIGATION ; SYSTEM ; AGENT
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81227901 ; International Innovation Team, CAS(20140491524) ; 81527805 ; 61231004 ; 61501462)
WOS研究方向Medical Laboratory Technology ; General & Internal Medicine ; Research & Experimental Medicine
WOS类目Medical Laboratory Technology ; Medicine, General & Internal ; Medicine, Research & Experimental
WOS记录号WOS:000389106000007
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13358
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China
2.Key Lab Mol Imaging Beijing, Beijing, Peoples R China
3.Gen Hosp Peoples Liberat Army, Dept Gen Surg, Beijing, Peoples R China
4.Shantou Univ, Canc Hosp, Breast Ctr, Coll Med, Shantou, Peoples R China
5.Wannna Med Coll, Yijishan Hosp, Dept Thyroid & Breast Surg, Wuhu, Peoples R China
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He, Kunshan,Chi, Chongwei,Kou, Deqiang,et al. Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals[J]. TRANSLATIONAL RESEARCH,2016(178):74-80.
APA He, Kunshan.,Chi, Chongwei.,Kou, Deqiang.,Huang, Wenhe.,Wu, Jundong.,...&Tian, Jie.(2016).Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals.TRANSLATIONAL RESEARCH(178),74-80.
MLA He, Kunshan,et al."Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals".TRANSLATIONAL RESEARCH .178(2016):74-80.
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