CASIA OpenIR  > 中国科学院分子影像重点实验室
Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals
He, Kunshan; Chi, Chongwei; Kou, Deqiang; Huang, Wenhe; Wu, Jundong; Wang, Yabing; He, Lifang; Ye, Jinzuo; Mao, Yamin; Zhang, Guo-Jun; Wang, Jiandong; Tian, Jie
Source PublicationTRANSLATIONAL RESEARCH
2016-12-01
Issue178Pages:74-80
SubtypeArticle
AbstractSentinel lymph node biopsy (SLNB) has become a standard of care to detect axillary lymph metastasis in early-stage breast cancer patients with clinically negative axillary lymph nodes. Current SLNB detection modalities comprising a blue dye, a radioactive tracer, or a combination of both have advantages as well as disadvantages. Thus, near-infrared fluorescence imaging using indocyanine green (ICG) has recently been regarded as a novel method that has generated interest for SLNB around the world. However, the lack of appropriate fluorescence imaging systems has hindered further research and wide application of this method. Therefore, we developed novel fluorescence image-guided resection equipment (FIRE) to detect sentinel lymph nodes (SLNs). Moreover, to compare the ICG fluorescence imaging method with the blue dye method and to explore the universal feasibility of the former, a different type of hospital study was conducted. Ninety-nine eligible patients participated in the study at 3 different types of hospitals. After subcutaneous ICG allergy testing, all the patients were subcutaneously injected with methylene blue and ICG into the subareolar area. Consequently, 276 SLNs (range 1-7) were identified in 98 subjects (detection rate: 99%) by using the ICG fluorescence imaging method. In contrast, the blue dye method only identified 202 SLNs (range 1-7) in 91 subjects (detection rate: 91.92%). Besides, the results of the fluorescence imaging method were similar in the 3 hospitals. Our findings indicate the universal feasibility of the ICG fluorescence imaging method for SLNB using the fluorescence image-guided resection equipment in early breast cancer detection.
KeywordIndocyanine Green Fluorescence
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.trs1.2016.07.010
WOS KeywordBREAST-CANCER PATIENTS ; SURGERY ; TRIAL ; IDENTIFICATION ; NAVIGATION ; SYSTEM ; AGENT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81227901 ; International Innovation Team, CAS(20140491524) ; 81527805 ; 61231004 ; 61501462)
WOS Research AreaMedical Laboratory Technology ; General & Internal Medicine ; Research & Experimental Medicine
WOS SubjectMedical Laboratory Technology ; Medicine, General & Internal ; Medicine, Research & Experimental
WOS IDWOS:000389106000007
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13358
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China
2.Key Lab Mol Imaging Beijing, Beijing, Peoples R China
3.Gen Hosp Peoples Liberat Army, Dept Gen Surg, Beijing, Peoples R China
4.Shantou Univ, Canc Hosp, Breast Ctr, Coll Med, Shantou, Peoples R China
5.Wannna Med Coll, Yijishan Hosp, Dept Thyroid & Breast Surg, Wuhu, Peoples R China
Recommended Citation
GB/T 7714
He, Kunshan,Chi, Chongwei,Kou, Deqiang,et al. Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals[J]. TRANSLATIONAL RESEARCH,2016(178):74-80.
APA He, Kunshan.,Chi, Chongwei.,Kou, Deqiang.,Huang, Wenhe.,Wu, Jundong.,...&Tian, Jie.(2016).Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals.TRANSLATIONAL RESEARCH(178),74-80.
MLA He, Kunshan,et al."Comparison between the indocyanine green fluorescence and blue dye methods for sentinel lymph node biopsy using novel fluorescence image-guided resection equipment in different types of hospitals".TRANSLATIONAL RESEARCH .178(2016):74-80.
Files in This Item: Download All
File Name/Size DocType Version Access License
TransResearch-乳腺癌(何)(851KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[He, Kunshan]'s Articles
[Chi, Chongwei]'s Articles
[Kou, Deqiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[He, Kunshan]'s Articles
[Chi, Chongwei]'s Articles
[Kou, Deqiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[He, Kunshan]'s Articles
[Chi, Chongwei]'s Articles
[Kou, Deqiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: TransResearch-乳腺癌(何).pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.