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Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET
Liu, Shuai1,2; Wang, Yinyan3; Xu, Kaibin4,5; Ping, Fan2,6; Wang, Renzhi1,2; Li, Fang2,7; Cheng, Xin2,7
Source PublicationNEUROIMAGE-CLINICAL
2016
Volume12Pages:415-419
SubtypeArticle
AbstractChronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using F-18-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral F-18-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum-cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
KeywordCushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2016.08.018
WOS KeywordPITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; HIPPOCAMPAL ATROPHY ; CORTISOL-LEVELS ; STRESS ; MEMORY ; VOLUME ; TRANSPORT ; NEURONS ; RAT
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81201121)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000390196400048
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13362
Collection脑网络组研究中心
Affiliation1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
2.Peking Union Med Coll, Beijing 100730, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET[J]. NEUROIMAGE-CLINICAL,2016,12:415-419.
APA Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Wang, Renzhi.,...&Cheng, Xin.(2016).Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.NEUROIMAGE-CLINICAL,12,415-419.
MLA Liu, Shuai,et al."Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET".NEUROIMAGE-CLINICAL 12(2016):415-419.
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