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Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET
Liu, Shuai1,2; Wang, Yinyan3; Xu, Kaibin4,5; Ping, Fan2,6; Wang, Renzhi1,2; Li, Fang2,7; Cheng, Xin2,7
2016
发表期刊NEUROIMAGE-CLINICAL
卷号12页码:415-419
文章类型Article
摘要Chronic exposure to elevated levels of glucocorticoids can exert a neurotoxic effect in patients, possibly manifesting as molecular imaging alterations in patients. The aim of this study was to investigate the potential association between brain metabolism and elevated hormone level using F-18-fluorodeoxyglucose positron emission tomography. We retrospectively enrolled 92 consecutive patients with confirmed diagnosis of Cushing's disease. A voxel-based analysis was performed to investigate the association between cerebral F-18-fluorodeoxyglucose uptake and serum cortisol level. Relatively impaired metabolism of specific brain regions correlated with serum-cortisol level was found. Specifically, notable correlations were found in the hippocampus, amygdala, and cerebellum, regions considered to be involved in the regulation and central action of glucocorticoids. Moreover, some hormone-associated regions were found in the frontal and occipital cortex, possibly mediating the cognitive changes seen in Cushing's disease. Our findings link patterns of perturbed brain metabolism relates to individual hormone level, thus presenting a substrate for cognitive disturbances seen in Cushing's disease patients, as well as in other conditions with abnormal cortisol levels. (C) 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
关键词Cushing's Disease Positron Emission Tomography Cortisol Voxel-based Analysis
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2016.08.018
关键词[WOS]PITUITARY-ADRENOCORTICAL AXIS ; ANTERIOR CINGULATE CORTEX ; HIPPOCAMPAL ATROPHY ; CORTISOL-LEVELS ; STRESS ; MEMORY ; VOLUME ; TRANSPORT ; NEURONS ; RAT
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81201121)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000390196400048
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13362
专题脑网络组研究中心
作者单位1.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
2.Peking Union Med Coll, Beijing 100730, Peoples R China
3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Endocrinol, Beijing, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nucl Med, Beijing 100730, Peoples R China
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GB/T 7714
Liu, Shuai,Wang, Yinyan,Xu, Kaibin,et al. Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET[J]. NEUROIMAGE-CLINICAL,2016,12:415-419.
APA Liu, Shuai.,Wang, Yinyan.,Xu, Kaibin.,Ping, Fan.,Wang, Renzhi.,...&Cheng, Xin.(2016).Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.NEUROIMAGE-CLINICAL,12,415-419.
MLA Liu, Shuai,et al."Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET".NEUROIMAGE-CLINICAL 12(2016):415-419.
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