MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles

doi:10.1016/j.biomaterials.2016.10.011

	MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
	Qiao, Hongyu 1,2; Wang, Yabin 1; Zhang, Ruohan 3; Gao, Quansheng 6; Liang, Xiao4 ; Gao, Lei 1; Jiang, Zhenhua 2; Qiao, Ruirui 5; Han, Dong 2; Zhang, Yan 1; Qiu, Ya 1; Tian, Jie 4; Gao, Mingyuan 5; Cao, Feng 1,2
发表期刊	BIOMATERIALS
	2017
卷号	112 页码:336-345
文章类型	Article
摘要	Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 +/- 0.19 x 10(10) vs. 0.74 +/- 0.04 x 10(10), 0.73 +/- 0.03 x 10(10) p/sec/cm(2)/sr, P < 0.05). Meanwhile, MRI displayed stronger T-2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 +/- 0.04 vs. 0.95 +/- 0.02, 0.98 +/- 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
关键词	Dual-modality Molecular Imaging Atherosclerotic Plaques Macrophages Nanoparticles
WOS标题词	Science & Technology ; Technology
DOI	10.1016/j.biomaterials.2016.10.011
关键词[WOS]	CONTRAST-ENHANCED ULTRASOUND ; CORONARY-ARTERY-DISEASE ; MAGNETIC-RESONANCE ; IN-VIVO ; IRON-OXIDE ; FUTURE-DIRECTIONS ; TRANSGENIC MICE ; DEFICIENT MICE ; SMOOTH-MUSCLE ; MACROPHAGE
收录类别	SCI
语种	英语
项目资助者	National Key Research Program of China(2016YFA0100903) ; National Funds for Distinguished Young Scientists of China(81325009) ; National Nature Science Foundation of China(81500360 ; Beijing Nature Science Foundation(7152131) ; China Postdoctoral Science Foundation(2016790990) ; 81671731 ; 81530058 ; 81570272)
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:000389166700029
引用统计	被引频次：67[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/13365
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese PM Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China 2.Dept Cardiol, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary & Pancretosplen Surg, Xian 710032, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 6.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Hongyu,Wang, Yabin,Zhang, Ruohan,et al. MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles[J]. BIOMATERIALS,2017,112:336-345.
APA	Qiao, Hongyu.,Wang, Yabin.,Zhang, Ruohan.,Gao, Quansheng.,Liang, Xiao.,...&Cao, Feng.(2017).MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles.BIOMATERIALS,112,336-345.
MLA	Qiao, Hongyu,et al."MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles".BIOMATERIALS 112(2017):336-345.