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A lateralized top-down network for visuospatial attention and neglect
Wang, Jiaojian1; Tian, Yanghua4; Wang, Mengzhu1; Cao, Long1; Wu, Huawang1; Zhang, Yun1; Wang, Kai4; Jiang, Tianzi1,2,3,5
2016-12-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号10期号:4页码:1029-1037
文章类型Article
摘要The lateralization of visuospatial attention has been well investigated and demonstrated to be primarily resulting from unbalanced interaction between interhemispheric fronto-parietal networks in previous studies. Many recent studies of top-down attention have reported the neural signatures of its effects within visual cortex and identified its causal basis. However, the relationship between top-down networks and asymmetric visuospatial attention has not been well studied. In the current study, we aimed to explore the relationship between top-down connectivity and asymmetric visuospatial ability by using repetitive transcranial magnetic stimulation (rTMS) and resting-state functional connectivity (RSFC) analyses. We used rTMS and RSFC to model the virtual lesion to assess the behavioral performances in visuospatial attention shifting and to identify the behavior-related top-down functional connectivities, respectively. Furthermore, we also investigated the top-down connectivity in neglect patients to validate the RSFC findings. RSFC analyses in healthy subjects and neglect patients consistently revealed that asymmetric visuospatial ability and visuospatial neglect were closely related to the bias of top-down functional connectivity between posterior superior parietal lobule (SPL) and V1. Our findings indicate that stronger top-down connectivity has stronger dominance on its corresponding visual field. We argue that an asymmetric top-down network may represent a possible neurophysiological substrate for the ongoing functional asymmetry of visuospatial attention, and its interhemispheric unbalanced interaction could contribute to the clinical manifestations of visuospatial neglect.
关键词Visuospatial Attention Neglect Superior Parietal Lobule Visual Cortex Tms
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-015-9460-y
关键词[WOS]TRANSCRANIAL MAGNETIC STIMULATION ; HUMAN PARIETAL CORTEX ; HUMAN VISUAL-CORTEX ; SPATIAL ATTENTION ; FUNCTIONAL CONNECTIVITY ; DIRECTED ATTENTION ; PREFRONTAL CORTEX ; CORTICAL MECHANISMS ; NEURAL MECHANISMS ; COVERT ATTENTION
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 program)(2011CB707801) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31500867 ; 91132301 ; 81100806)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000390015900009
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13377
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 625014, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Anhui Med Univ, Hosp 1, Dept Neurol, Hefei 230022, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
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Wang, Jiaojian,Tian, Yanghua,Wang, Mengzhu,et al. A lateralized top-down network for visuospatial attention and neglect[J]. BRAIN IMAGING AND BEHAVIOR,2016,10(4):1029-1037.
APA Wang, Jiaojian.,Tian, Yanghua.,Wang, Mengzhu.,Cao, Long.,Wu, Huawang.,...&Jiang, Tianzi.(2016).A lateralized top-down network for visuospatial attention and neglect.BRAIN IMAGING AND BEHAVIOR,10(4),1029-1037.
MLA Wang, Jiaojian,et al."A lateralized top-down network for visuospatial attention and neglect".BRAIN IMAGING AND BEHAVIOR 10.4(2016):1029-1037.
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