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A lateralized top-down network for visuospatial attention and neglect
Wang, Jiaojian1; Tian, Yanghua4; Wang, Mengzhu1; Cao, Long1; Wu, Huawang1; Zhang, Yun1; Wang, Kai4; Jiang, Tianzi1,2,3,5
Source PublicationBRAIN IMAGING AND BEHAVIOR
2016-12-01
Volume10Issue:4Pages:1029-1037
SubtypeArticle
AbstractThe lateralization of visuospatial attention has been well investigated and demonstrated to be primarily resulting from unbalanced interaction between interhemispheric fronto-parietal networks in previous studies. Many recent studies of top-down attention have reported the neural signatures of its effects within visual cortex and identified its causal basis. However, the relationship between top-down networks and asymmetric visuospatial attention has not been well studied. In the current study, we aimed to explore the relationship between top-down connectivity and asymmetric visuospatial ability by using repetitive transcranial magnetic stimulation (rTMS) and resting-state functional connectivity (RSFC) analyses. We used rTMS and RSFC to model the virtual lesion to assess the behavioral performances in visuospatial attention shifting and to identify the behavior-related top-down functional connectivities, respectively. Furthermore, we also investigated the top-down connectivity in neglect patients to validate the RSFC findings. RSFC analyses in healthy subjects and neglect patients consistently revealed that asymmetric visuospatial ability and visuospatial neglect were closely related to the bias of top-down functional connectivity between posterior superior parietal lobule (SPL) and V1. Our findings indicate that stronger top-down connectivity has stronger dominance on its corresponding visual field. We argue that an asymmetric top-down network may represent a possible neurophysiological substrate for the ongoing functional asymmetry of visuospatial attention, and its interhemispheric unbalanced interaction could contribute to the clinical manifestations of visuospatial neglect.
KeywordVisuospatial Attention Neglect Superior Parietal Lobule Visual Cortex Tms
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-015-9460-y
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; HUMAN PARIETAL CORTEX ; HUMAN VISUAL-CORTEX ; SPATIAL ATTENTION ; FUNCTIONAL CONNECTIVITY ; DIRECTED ATTENTION ; PREFRONTAL CORTEX ; CORTICAL MECHANISMS ; NEURAL MECHANISMS ; COVERT ATTENTION
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 program)(2011CB707801) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(31500867 ; 91132301 ; 81100806)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000390015900009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/13377
Collection脑网络组研究中心
Affiliation1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 625014, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Anhui Med Univ, Hosp 1, Dept Neurol, Hefei 230022, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Wang, Jiaojian,Tian, Yanghua,Wang, Mengzhu,et al. A lateralized top-down network for visuospatial attention and neglect[J]. BRAIN IMAGING AND BEHAVIOR,2016,10(4):1029-1037.
APA Wang, Jiaojian.,Tian, Yanghua.,Wang, Mengzhu.,Cao, Long.,Wu, Huawang.,...&Jiang, Tianzi.(2016).A lateralized top-down network for visuospatial attention and neglect.BRAIN IMAGING AND BEHAVIOR,10(4),1029-1037.
MLA Wang, Jiaojian,et al."A lateralized top-down network for visuospatial attention and neglect".BRAIN IMAGING AND BEHAVIOR 10.4(2016):1029-1037.
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