| Decreased Thalamocortical Connectivity in Chronic Ketamine Users | |
Liao, Yanhui1,2; Tang, Jinsong1,2; Liu, Jianbin3; Xie, An3; Yang, Mei1,4,5; Johnson, Maritza2; Wang, Xuyi1; Deng, Qijian1; Chen, Hongxian1; Xiang, Xiaojun1; Liu, Tieqiao1; Chen, Xiaogang1; Song, Ming6,7 ; Hao, Wei1
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| 发表期刊 | PLOS ONE
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| 2016-12-15 | |
| 卷号 | 11期号:12页码:1 |
| 文章类型 | Article |
| 摘要 | Disintegration in thalamocortical integration suggests its role in the mechanistic 'switch' from recreational to dysregulated drug seeking/addiction. In this study, we aimed to address whether thalamic nuclear groups show altered functional connectivity within the cerebral cortex in chronic ketamine users. One hundred and thirty subjects (41 ketamine users and 89 control subjects) underwent rsfMRI (resting-state functional Magnetic Resonance Imaging). Based on partial correlation functional connectivity analysis we partitioned the thalamus into six nuclear groups that correspond well with human histology. Then, in the area of each nuclear group, the functional connectivity differences between the chronic ketamine user group and normal control group were investigated. We found that the ketamine user group showed significantly less connectivity between the thalamic nuclear groups and the cortical regions-of-interest, including the prefrontal cortex, the motor cortex/supplementary motor area, and the posterior parietal cortex. However, no increased thalamic connectivity was observed for these regions as compared with controls. This study provides the first evidence of abnormal thalamocortical connectivity of resting state brain activity in chronic ketamine users. Further understanding of pathophysiological mechanisms of the thalamus in addiction (ketamine addiction) may facilitate the evaluation of much-needed novel pharmacological agents for improved therapy of this complex disease. |
| 关键词 | Ketamine Brain Network |
| WOS标题词 | Science & Technology |
| DOI | 10.1371/journal.pone.0167381 |
| 关键词[WOS] | STATE FUNCTIONAL CONNECTIVITY ; NONMEDICAL USE ; THALAMUS ; CORTEX ; SCHIZOPHRENIA ; ADDICTION ; BRAIN ; NEUROBIOLOGY ; DEPENDENCE ; SYMPTOMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | Natural Science Foundation of China(81100996 ; Beijing Municipal Science & Technology Commission(Z161100000216152) ; Hunan Province '225' training project ; 81671325 ; 81101040 ; 81471380 ; 81371480 ; 81371465 ; 81130020) |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000391217400018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/13383 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth,Key Lab Psychiat & Mental Hlth H, China Natl Clin Res Ctr Mental Hlth Disorders,Nat, Changsha, Hunan, Peoples R China 2.Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA 3.Peoples Hosp Hunan Prov, Dept Radiol, Changsha, Hunan, Peoples R China 4.Hunan Brain Hosp, Dept Addict Med, Changsha, Hunan, Peoples R China 5.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Addict Med, Shenzhen, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Yanhui,Tang, Jinsong,Liu, Jianbin,et al. Decreased Thalamocortical Connectivity in Chronic Ketamine Users[J]. PLOS ONE,2016,11(12):1. |
| APA | Liao, Yanhui.,Tang, Jinsong.,Liu, Jianbin.,Xie, An.,Yang, Mei.,...&Hao, Wei.(2016).Decreased Thalamocortical Connectivity in Chronic Ketamine Users.PLOS ONE,11(12),1. |
| MLA | Liao, Yanhui,et al."Decreased Thalamocortical Connectivity in Chronic Ketamine Users".PLOS ONE 11.12(2016):1. |
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