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In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography
Hu, Zhenhua1,2; Zhao, Mingxuan3; Qu, Yawei4; Zhang, Xiaojun5; Zhang, Mingru3; Liu, Muhan1; Guo, Hongbo1; Zhang, Zeyu1; Wang, Jing3; Yang, Weidong3; Tian, Jie1,2
2017
发表期刊JOURNAL OF NUCLEAR MEDICINE
卷号58期号:1页码:169-174
文章类型Article
摘要Cerenkov luminescence imaging can image radiopharmaceuticals using a high-sensitivity charge-coupled device camera. However, Cerenkov luminescence emitted from the radiopharmaceuticals is weak and has low penetration depth in biologic tissues, which severely limits the sensitivity and accuracy of Cerenkov luminescence imaging. This study presents 3-dimensional (3D) radiophamiaceutical-excited fluorescence tomography (REFT) using europium oxide (EO) nanoparticles, which enhances the Cerenkov luminescence signal intensity, improves the penetration depth, and obtains more accurate 3D distribution of radiopharmaceuticals. Methods: The enhanced optical signals of various radiopharmaceuticals (including F-18-FDG, (GaCl3)-Ga-68, Na(99)mTcO(4)) by EO nanoparticles were detected in vitro. The location and 3D distribution of the radiopharmaceuticals of REFT were then reconstructed and compared with those of Cerenkov luminescence tomography through the experiments with the phantom, artificial source-implanted mouse models, and mice bearing hepatocellular carcinomas. Results: The mixture of (GaCl3)-Ga-68 and EO nanoparticles possessed the strongest optical signals compared with the other mixtures. The in vitro phantom and implanted mouse studies showed that REFT revealed more accurate 3D distribution of (GaCl3)-Ga-68. REFT can detect more tumors than small-animal PET in hepatocellular carcinoma-bearing mice and achieved more accurate 3D distribution information than Cerenkov luminescence tomography. Conclusion: REFT with EO nanoparticles significantly improves accuracy of localization of radiopharmaceuticals and can precisely localize the tumor in vivo.
关键词Radiopharmaceutical Excitation Fluorescence Tomography (Reft) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Pet
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.2967/jnumed.116.180596
关键词[WOS]CERENKOV LUMINESCENCE TOMOGRAPHY ; MOUSE MODEL ; RADIONUCLIDE ; ENDOSCOPY
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; Beijing Municipal Science and Technology Commission(Z151100001615012) ; 81371594 ; 61231004 ; 81527805 ; 61302024 ; 81230033 ; 81471700)
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
WOS类目Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000391343400036
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/13387
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China
4.Gen Hosp Chinese Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China
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Hu, Zhenhua,Zhao, Mingxuan,Qu, Yawei,et al. In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography[J]. JOURNAL OF NUCLEAR MEDICINE,2017,58(1):169-174.
APA Hu, Zhenhua.,Zhao, Mingxuan.,Qu, Yawei.,Zhang, Xiaojun.,Zhang, Mingru.,...&Tian, Jie.(2017).In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography.JOURNAL OF NUCLEAR MEDICINE,58(1),169-174.
MLA Hu, Zhenhua,et al."In Vivo 3-Dimensional Radiopharmaceutical-Excited Fluorescence Tomography".JOURNAL OF NUCLEAR MEDICINE 58.1(2017):169-174.
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