CASIA OpenIR  > 中国科学院分子影像重点实验室
Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging
Li, Na1; Wang, Jia-Bo2; Zhao, Yan-Ling2; Zhang, Lin2; Ma, Xi-Bo3; Li, Xiao-Fei2; Song, Jie1; Yang, Xin3; Xiao, Xiao-He2; Tian, Jie3; Kang, Ting-Guo1
Source PublicationINTERNATIONAL JOURNAL OF PHARMACOLOGY
2017
Volume13Issue:2Pages:175-182
SubtypeArticle
AbstractBackground: Hepatocytes damage is sometimes closely related to oxidative stress and reactive oxygen species which are the major contributors to lipopolysaccharide-induced liver injury. Emodin, the active natural product in rhubarb of hydroxyanthraquinone skeleton, has been reported of protective activity to liver tissue, whose mechanism is generally thought of antioxidation based on chemical reaction or indirect evidence. There is no visualized evidence proved the reactive oxygen species scavenging effect of emodin in vivo. Materials and Methods: The dynamic reactive oxygen species luminescent signal in mice injured by bacillus calmette guerin and lipopolysaccharide was monitored by using the optical molecular imaging approach. Results: The elevations of serum alanine aminotransferase and aspartate transaminase activities in bacillus calmette guerin/lipopolysaccharide-injured mice were reversed by emodin, indicating the protection of emodin to hepatocytes. And emodin significantly and dose-dependently attenuated the reactive oxygen species luminescent signal elicited by bacillus calmette guerin/lipopolysaccharide, indicating visually the in vivo reactive oxygen species scavenging effect of emodin. In addition, emodin significantly and dose-dependently elevated the activity of superoxide dismutase, content of reduced glutathione and total antioxidant capacity and meanwhile decreased the contents of hydrogen peroxide, lipid peroxides and malondialdehyde in livers of bacillus calmette guerin/lipopolysaccharide-injured mice. It could be attributed to the anti-oxidative effect of emodin which helps to maintain the reactive oxygen species balance in vivo. Conclusion: Emodin can protect liver against bacillus calmette guerin/lipopolysaccharide-induced injury and the mechanism includes reactive oxygen species scavenging effect and anti-lipid peroxidation at least.
KeywordEmodin Hepatoprotection Reactive Oxygen Species Molecular Imaging Lipopolysaccharide Nuclear Factor Kappa b Anti-oxidation Alanine Aminotransferase Aspartate Transaminase
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3923/ijp.2017.175.182
WOS KeywordIN-VIVO ; OXIDATIVE STRESS ; TNF-ALPHA ; LIPID-PEROXIDATION ; KAPPA-B ; RATS ; DAMAGE ; ACTIVATION ; ROS ; INFLAMMATION
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81373984 ; National Industry Program of China(201207002) ; National Key Technology R and D Program(2012BAI29B02 ; 81274026 ; 206030201) ; 30572336)
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000392882700007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14367
Collection中国科学院分子影像重点实验室
Affiliation1.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Liaoning, Peoples R China
2.302 Mil Hosp, Integrat Med Ctr, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Na,Wang, Jia-Bo,Zhao, Yan-Ling,et al. Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2017,13(2):175-182.
APA Li, Na.,Wang, Jia-Bo.,Zhao, Yan-Ling.,Zhang, Lin.,Ma, Xi-Bo.,...&Kang, Ting-Guo.(2017).Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging.INTERNATIONAL JOURNAL OF PHARMACOLOGY,13(2),175-182.
MLA Li, Na,et al."Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging".INTERNATIONAL JOURNAL OF PHARMACOLOGY 13.2(2017):175-182.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Na]'s Articles
[Wang, Jia-Bo]'s Articles
[Zhao, Yan-Ling]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Na]'s Articles
[Wang, Jia-Bo]'s Articles
[Zhao, Yan-Ling]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Na]'s Articles
[Wang, Jia-Bo]'s Articles
[Zhao, Yan-Ling]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.