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Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging
Li, Na1; Wang, Jia-Bo2; Zhao, Yan-Ling2; Zhang, Lin2; Ma, Xi-Bo3; Li, Xiao-Fei2; Song, Jie1; Yang, Xin3; Xiao, Xiao-He2; Tian, Jie3; Kang, Ting-Guo1
2017
发表期刊INTERNATIONAL JOURNAL OF PHARMACOLOGY
卷号13期号:2页码:175-182
文章类型Article
摘要Background: Hepatocytes damage is sometimes closely related to oxidative stress and reactive oxygen species which are the major contributors to lipopolysaccharide-induced liver injury. Emodin, the active natural product in rhubarb of hydroxyanthraquinone skeleton, has been reported of protective activity to liver tissue, whose mechanism is generally thought of antioxidation based on chemical reaction or indirect evidence. There is no visualized evidence proved the reactive oxygen species scavenging effect of emodin in vivo. Materials and Methods: The dynamic reactive oxygen species luminescent signal in mice injured by bacillus calmette guerin and lipopolysaccharide was monitored by using the optical molecular imaging approach. Results: The elevations of serum alanine aminotransferase and aspartate transaminase activities in bacillus calmette guerin/lipopolysaccharide-injured mice were reversed by emodin, indicating the protection of emodin to hepatocytes. And emodin significantly and dose-dependently attenuated the reactive oxygen species luminescent signal elicited by bacillus calmette guerin/lipopolysaccharide, indicating visually the in vivo reactive oxygen species scavenging effect of emodin. In addition, emodin significantly and dose-dependently elevated the activity of superoxide dismutase, content of reduced glutathione and total antioxidant capacity and meanwhile decreased the contents of hydrogen peroxide, lipid peroxides and malondialdehyde in livers of bacillus calmette guerin/lipopolysaccharide-injured mice. It could be attributed to the anti-oxidative effect of emodin which helps to maintain the reactive oxygen species balance in vivo. Conclusion: Emodin can protect liver against bacillus calmette guerin/lipopolysaccharide-induced injury and the mechanism includes reactive oxygen species scavenging effect and anti-lipid peroxidation at least.
关键词Emodin Hepatoprotection Reactive Oxygen Species Molecular Imaging Lipopolysaccharide Nuclear Factor Kappa b Anti-oxidation Alanine Aminotransferase Aspartate Transaminase
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3923/ijp.2017.175.182
关键词[WOS]IN-VIVO ; OXIDATIVE STRESS ; TNF-ALPHA ; LIPID-PEROXIDATION ; KAPPA-B ; RATS ; DAMAGE ; ACTIVATION ; ROS ; INFLAMMATION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81373984 ; National Industry Program of China(201207002) ; National Key Technology R and D Program(2012BAI29B02 ; 81274026 ; 206030201) ; 30572336)
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000392882700007
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14367
专题中国科学院分子影像重点实验室
作者单位1.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Liaoning, Peoples R China
2.302 Mil Hosp, Integrat Med Ctr, Beijing 100039, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Li, Na,Wang, Jia-Bo,Zhao, Yan-Ling,et al. Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging[J]. INTERNATIONAL JOURNAL OF PHARMACOLOGY,2017,13(2):175-182.
APA Li, Na.,Wang, Jia-Bo.,Zhao, Yan-Ling.,Zhang, Lin.,Ma, Xi-Bo.,...&Kang, Ting-Guo.(2017).Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging.INTERNATIONAL JOURNAL OF PHARMACOLOGY,13(2),175-182.
MLA Li, Na,et al."Liver Protective and Reactive Oxygen Species Scavenging Effects of Emodin in Lipopolysaccharide/Bacillus Calmette Guerin-injured Mice by Optical Molecular Imaging".INTERNATIONAL JOURNAL OF PHARMACOLOGY 13.2(2017):175-182.
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