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In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics
Lv, Ruichan1,2,4; Yang, Piaoping2; Hu, Bo1; Xu, Jiating2; Shang, Wenting3; Tian, Jie1,3
2017
发表期刊ACS NANO
卷号11期号:1页码:1064-1072
文章类型Article
摘要In the theranostic field, a near-infrared (NIR) laser is located in the optical window, and up-conversion nanoparticles (UCNPs) could be potentially utilized as the imaging agents with high contrast. Meanwhile, copper sulfide (CuS) has been proposed as a photothermal agent with increased temperature under a NIR laser. However, there is still no direct and effective strategy to integrate the hydrophobic UCNPs with CuS until now. Herein, we propose an in situ growth routine based on the hydrophobic core/shell UCNPs combined with ultrasmall water-soluble CuS triggered by single 808 run MR irradiation as the theranostic platform. Hydrophobic NaYF4:Yb,Er@NaYF4,Nd,Yb could be turned hydrophilic with highly dispersed and biocompatible properties through conjunction with transferred dopamine. The as-synthesized ultrasmall CuS (3 and 7 nm) served as a stable photothermal agent even after several laser-on/off cycles. Most importantly, comparing with the mix routine, the in situ growth routine to coat UCNPs with CuS is meaningful, and the platform is uniform and stable. Green luminescence-guided hyperthermia could be achieved under a single 808 nm laser, which was evidenced by in vitro and in vivo assays. This nanoplatform is applicable as a bioimaging and photothermal antitumor agent, and the in situ growth routine could be spread to other integration processes.
关键词Up-conversion Copper Sulfide In Situ Growth Photothermal
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.6b07990
关键词[WOS]NEAR-INFRARED-LIGHT ; CORE-SHELL NANOPARTICLES ; UPCONVERTING NANOPARTICLES ; LUMINESCENCE ENHANCEMENT ; BIOMEDICAL APPLICATIONS ; THERAPY ; VIVO ; TUMOR ; NANORODS ; PLATFORM
收录类别SCI
语种英语
项目资助者Natural Science Foundation of China(NSFC 21271053 ; Alexander von Humboldt Foundation ; 21401032 ; 51472058 ; 51332008 ; 51502050)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000392886500112
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14369
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710071, Shanxi, Peoples R China
2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Philipps Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany
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GB/T 7714
Lv, Ruichan,Yang, Piaoping,Hu, Bo,et al. In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics[J]. ACS NANO,2017,11(1):1064-1072.
APA Lv, Ruichan,Yang, Piaoping,Hu, Bo,Xu, Jiating,Shang, Wenting,&Tian, Jie.(2017).In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics.ACS NANO,11(1),1064-1072.
MLA Lv, Ruichan,et al."In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics".ACS NANO 11.1(2017):1064-1072.
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