CASIA OpenIR  > 中国科学院分子影像重点实验室
In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics
Lv, Ruichan1,2,4; Yang, Piaoping2; Hu, Bo1; Xu, Jiating2; Shang, Wenting3; Tian, Jie1,3
Source PublicationACS NANO
2017
Volume11Issue:1Pages:1064-1072
SubtypeArticle
AbstractIn the theranostic field, a near-infrared (NIR) laser is located in the optical window, and up-conversion nanoparticles (UCNPs) could be potentially utilized as the imaging agents with high contrast. Meanwhile, copper sulfide (CuS) has been proposed as a photothermal agent with increased temperature under a NIR laser. However, there is still no direct and effective strategy to integrate the hydrophobic UCNPs with CuS until now. Herein, we propose an in situ growth routine based on the hydrophobic core/shell UCNPs combined with ultrasmall water-soluble CuS triggered by single 808 run MR irradiation as the theranostic platform. Hydrophobic NaYF4:Yb,Er@NaYF4,Nd,Yb could be turned hydrophilic with highly dispersed and biocompatible properties through conjunction with transferred dopamine. The as-synthesized ultrasmall CuS (3 and 7 nm) served as a stable photothermal agent even after several laser-on/off cycles. Most importantly, comparing with the mix routine, the in situ growth routine to coat UCNPs with CuS is meaningful, and the platform is uniform and stable. Green luminescence-guided hyperthermia could be achieved under a single 808 nm laser, which was evidenced by in vitro and in vivo assays. This nanoplatform is applicable as a bioimaging and photothermal antitumor agent, and the in situ growth routine could be spread to other integration processes.
KeywordUp-conversion Copper Sulfide In Situ Growth Photothermal
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.6b07990
WOS KeywordNEAR-INFRARED-LIGHT ; CORE-SHELL NANOPARTICLES ; UPCONVERTING NANOPARTICLES ; LUMINESCENCE ENHANCEMENT ; BIOMEDICAL APPLICATIONS ; THERAPY ; VIVO ; TUMOR ; NANORODS ; PLATFORM
Indexed BySCI
Language英语
Funding OrganizationNatural Science Foundation of China(NSFC 21271053 ; Alexander von Humboldt Foundation ; 21401032 ; 51472058 ; 51332008 ; 51502050)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000392886500112
Citation statistics
Cited Times:53[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14369
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710071, Shanxi, Peoples R China
2.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Philipps Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany
Recommended Citation
GB/T 7714
Lv, Ruichan,Yang, Piaoping,Hu, Bo,et al. In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics[J]. ACS NANO,2017,11(1):1064-1072.
APA Lv, Ruichan,Yang, Piaoping,Hu, Bo,Xu, Jiating,Shang, Wenting,&Tian, Jie.(2017).In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics.ACS NANO,11(1),1064-1072.
MLA Lv, Ruichan,et al."In Situ Growth Strategy to Integrate Up-Conversion Nanoparticles with Ultrasmall CuS for Photothermal Theranostics".ACS NANO 11.1(2017):1064-1072.
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