CASIA OpenIR  > 中国科学院分子影像重点实验室
Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice
Cheng, Haidong1,2,3; Chi, Chongwei3; Shang, Wenting3; Sha Rengaowa4; Cui, Jianxin1; Ye, Jinzuo3; Jiang, Shixin3; Mao, Yamin3; Zeng, Caoting5; Huo, Huiping6; Chen, Lin1; Tian, Jie3
Source PublicationONCOTARGET
2017
Volume8Issue:4Pages:6258-6272
SubtypeArticle
AbstractPeritoneal carcinomatosis from gastric cancer represents a common recurrent gastric cancer that seriously affects the survival, prognosis, and quality of life of patients at its advanced stage. In recent years, complete cytoreduction surgery in combination with hyperthermic intraperitoneal chemotherapy has been demonstrated to improve the survival and prognosis of patients with malignant tumors including peritoneal carcinomatosis from gastric cancer. Establishing viable methods of accurately assessing the tumor burden in patients with peritoneal carcinoma and correctly selecting suitable patients in order to improve cytoreduction surgical outcomes and reduce the risk of postoperative complications has become a challenge in the field of peritoneal carcinoma research. Here, we investigated peritoneal carcinomatosis from gastric cancer in a mouse model by using our self-developed surgical navigation system that combines optical molecular imaging with an integrin-targeting Arg-Gly-Asp-indocyanine green (RGD-ICG) molecular probe. The results showed that our diagnostic method could achieve a sensitivity and specificity of up to 93.93% and 100%, respectively, with a diagnostic index (DI) of 193.93% and diagnostic accuracy rate of 93.93%. Furthermore, the minimum tumor diameter measured during the surgery was 1.8 mm and the operative time was shortened by 3.26-fold when compared with the conventionally-treated control group. Therefore, our surgical navigation system that combines optical molecular imaging with an RGD-ICG molecular probe, could improve the diagnostic accuracy rate for peritoneal carcinomatosis from gastric cancer, shorten the operative time, and improve the quality of the cytoreduction surgery for peritoneal carcinomatosis from gastric cancer, thus providing a solid foundation for its future clinical development and application.
KeywordGastric Cancer Fluorescence Molecular Imaging Peritoneal Carcinomatosis Integrin
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.14058
WOS KeywordHYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY ; CYTOREDUCTIVE SURGERY ; OVARIAN-CANCER ; BREAST-CANCER ; METASTASIS ; ALPHA(V)BETA(3) ; MANAGEMENT ; CHEMOHYPERTHERMIA ; MALIGNANCIES ; STATISTICS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81227901 ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201359) ; 61231004 ; 81470083 ; 61501462)
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000393289000072
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14371
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, Beijing, Peoples R China
2.Inner Mongolia Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hohhot 010059, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Inner Mongolia Med Univ, Dept Basic Med Sci, Hohhot 010059, Peoples R China
5.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
6.Peoples Liberat Army, Gen Hosp, Dept Ultrasound, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Haidong,Chi, Chongwei,Shang, Wenting,et al. Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice[J]. ONCOTARGET,2017,8(4):6258-6272.
APA Cheng, Haidong.,Chi, Chongwei.,Shang, Wenting.,Sha Rengaowa.,Cui, Jianxin.,...&Tian, Jie.(2017).Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice.ONCOTARGET,8(4),6258-6272.
MLA Cheng, Haidong,et al."Precise integrin-targeting near-infrared imaging-guided surgical method increases surgical qualification of peritoneal carcinomatosis from gastric cancer in mice".ONCOTARGET 8.4(2017):6258-6272.
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