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ASSOCIATIONS BETWEEN THE CNTNAP2 GENE, DORSOLATERAL PREFRONTAL CORTEX, AND COGNITIVE PERFORMANCE ON THE STROOP TASK
Zhu, Bi1,2,3,4; Chen, Chuansheng5; Xue, Gui1,2,3; Lei, Xuemei6; Wang, Yunxin7; Li, Jin8; Moyzis, Robert K.9,10; Li, Jun1,2,3; Dong, Qi1,2,3; Lin, Chongde1,2,3,4
2017-02-20
发表期刊NEUROSCIENCE
卷号343页码:21-29
文章类型Article
摘要The CNTNAP2 (contactin-associated protein-like 2) gene, highly expressed in the human prefrontal cortex, has been linked with autism and language impairment. Potential relationships between CNTNAP2, dorsolateral prefrontal cortex (DLPFC), and cognition have been suggested by previous clinical studies, but have not been directly examined in the same study. The current study collected structural MRI, genetic, and behavioral data in 317 healthy Chinese adults, and examined associations between CNTNAP2 variants, DLPFC, and cognitive performance (measured by the Stroop task). After controlling for intracranial volume, sex, and age, the CNTNAP2 genetic polymorphism at SNP rs7809486 had the strongest association with bilateral DLPFC volume (p = 0.00015 and 0.00014 for left and right DLPFC volumes, respectively), with GG homozygotes having greater bilateral DLPFC volumes and surface areas than the other genotypes. Furthermore, TT homozygotes of CNTNAP2 rs4726946 (a nearby SNP that had moderate linkage disequilibrium with rs7809486) had greater left DLPFC volume and surface area, and better cognitive performance than the other genotypes. Subjects with greater left DLPFC surface area had better cognitive performance. Importantly, the left DLPFC surface area mediated the association between the CNTNAP2 rs4726946 genotype and cognitive performance. This study provides the first evidence for associations among the CNTNAP2 gene, left DLPFC structure, and cognitive control. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词Dorsolateral Prefrontal Cortex Stroop Gene Mri Imaging Genetics
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroscience.2016.11.021
关键词[WOS]AUTISM SPECTRUM DISORDERS ; HEALTHY-INDIVIDUALS ; MAJOR DEPRESSION ; SCHIZOPHRENIA ; BRAIN ; POLYMORPHISM ; DYSFUNCTION ; POPULATION ; RISK ; SEGMENTATION
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(31571132 ; 973 Program(2014CB846102) ; 111 Project of the Ministry of Education of China(B07008) ; 31130025)
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000393269100003
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14372
专题脑网络组研究中心
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
3.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing, Peoples R China
4.Beijing Normal Univ, Inst Dev Psychol, Beijing, Peoples R China
5.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA USA
6.Beijing Normal Univ, Sch Psychol, Beijing, Peoples R China
7.Capital Inst Pediat, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
9.Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA
10.Univ Calif Irvine, Inst Genom & Bioinformat, Irvine, CA USA
推荐引用方式
GB/T 7714
Zhu, Bi,Chen, Chuansheng,Xue, Gui,et al. ASSOCIATIONS BETWEEN THE CNTNAP2 GENE, DORSOLATERAL PREFRONTAL CORTEX, AND COGNITIVE PERFORMANCE ON THE STROOP TASK[J]. NEUROSCIENCE,2017,343:21-29.
APA Zhu, Bi.,Chen, Chuansheng.,Xue, Gui.,Lei, Xuemei.,Wang, Yunxin.,...&Lin, Chongde.(2017).ASSOCIATIONS BETWEEN THE CNTNAP2 GENE, DORSOLATERAL PREFRONTAL CORTEX, AND COGNITIVE PERFORMANCE ON THE STROOP TASK.NEUROSCIENCE,343,21-29.
MLA Zhu, Bi,et al."ASSOCIATIONS BETWEEN THE CNTNAP2 GENE, DORSOLATERAL PREFRONTAL CORTEX, AND COGNITIVE PERFORMANCE ON THE STROOP TASK".NEUROSCIENCE 343(2017):21-29.
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