Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas

doi:10.18632/oncotarget.13970

	Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas
	Bai, Yan 1,2; Lin, Yusong 3,4; Zhang, Wei 5; Kong, Lingfei 2,6; Wang, Lifu 2,6; Zuo, Panli 7; Vallines, Ignacio 8; Schmitt, Benjamin 9; Tian, Jie 10; Song, Xiaolei 11; Zhou, Jinyuan 11; Wang, Meiyun 1,2
发表期刊	ONCOTARGET
	2017
卷号	8 期号:4 页码:5834-5842
文章类型	Article
摘要	Using noninvasive magnetic resonance imaging techniques to accurately evaluate the grading and cellularity of gliomas is beneficial for improving the patient outcomes. Amide proton transfer imaging is a noninvasive molecular magnetic resonance imaging technique based on chemical exchange saturation transfer mechanism that detects endogenous mobile proteins and peptides in biological tissues. Between August 2012 and November 2015, a total number of 44 patients with pathologically proven gliomas were included in this study. We compared the capability of amide proton transfer magnetic resonance imaging with that of noninvasive diffusion-weighted imaging and noninvasive 3-dimensional pseudo-continuous arterial spin imaging in evaluating the grading and cellularity of gliomas. Our results reveal that amide proton transfer magnetic resonance imaging is a superior imaging technique to diffusion-weighted imaging and 3-dimensional pseudo-continuous arterial spin imaging in the grading of gliomas. In addition, our results showed that the Ki-67 index correlated better with the amide proton transfer-weighted signal intensity than with the apparent diffusion coefficient value or the cerebral blood flow value in the gliomas. Amide proton transfer magnetic resonance imaging is a promising method for predicting the grading and cellularity of gliomas.
关键词	Amide Proton Transfer Glioma Grading Ki-67 Magnetic Resonance Imaging
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.18632/oncotarget.13970
关键词[WOS]	APPARENT DIFFUSION-COEFFICIENT ; HISTOGRAM ANALYSIS ; PERFUSION ; TUMOR ; CONTRAST ; PROLIFERATION ; SPECTROSCOPY ; GADOLINIUM ; MRI
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81271565 ; National Institutes of Health(R21-EB020905-01A1) ; Henan Province Scientific and Technological Innovation Talents Project(164200510014) ; Cooperation Project(152106000014) ; Key Project of Henan Medical Science and Technology Project(201501011) ; 31470047 ; 81601466)
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000393289000036
引用统计	被引频次：37[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/14375
专题	中国科学院分子影像重点实验室
作者单位	1.Zhengzhou Univ, Dept Radiol, Peoples Hosp, Zhengzhou, Henan, Peoples R China 2.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China 3.Zhengzhou Univ, Cooperat Innovat Ctr Internet Healthcare, Zhengzhou, Henan, Peoples R China 4.Zhengzhou Univ, Sch Software & Appl Technol, Zhengzhou, Henan, Peoples R China 5.Shanghai Jiao Tong Univ, Ren Ji Hosp, Dept Radiol, Shanghai, Peoples R China 6.Zhengzhou Univ, Dept Pathol, Peoples Hosp, Zhengzhou, Henan, Peoples R China 7.Siemens Healthcare China, MR Collaborat NE Asia, Beijing, Peoples R China 8.Siemens Healthcare China, MR Collaborat NE Asia, Shanghai, Peoples R China 9.Siemens Healthcare Australia, Imaging & Therapy Syst Div, Brisbane, Qld, Australia 10.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 11.Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA
推荐引用方式 GB/T 7714	Bai, Yan,Lin, Yusong,Zhang, Wei,et al. Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas[J]. ONCOTARGET,2017,8(4):5834-5842.
APA	Bai, Yan.,Lin, Yusong.,Zhang, Wei.,Kong, Lingfei.,Wang, Lifu.,...&Wang, Meiyun.(2017).Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas.ONCOTARGET,8(4),5834-5842.
MLA	Bai, Yan,et al."Noninvasive amide proton transfer magnetic resonance imaging in evaluating the grading and cellularity of gliomas".ONCOTARGET 8.4(2017):5834-5842.