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General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics
Yan, Hao1,2,3; Zhao, Lingyun1,2; Shang, Wenting4; Liu, Zhongqun1,2; Xie, Wensheng1,2; Qiang, Cai1,2; Xiong, Zhiyuan2; Zhang, Ranran1,2; Li, Baohua3; Sun, Xiaodan1,2; Kang, Feiyu1,3
2017-02-01
发表期刊NANO RESEARCH
卷号10期号:2页码:704-717
文章类型Article
摘要Recently, increasing attention has been paid to magneto-conjugated polymer core-shell nanoparticles (NPs) as theranostic platforms. However, the utilization of surfactants and extra oxidizing agents with potential toxicity in synthesis, the lack of general methods for the controlled synthesis of various kinds of magnetic NP (MNP)@conjugated polymer NPs, and the difficulty of obtaining balanced magneto-optical properties have greatly limited the applications of magneto-conjugated polymers in theranostics. We developed an in situ surface polymerization method free of extra surfactants and oxidizing agents to synthesize MNP@polypyrrole (PPy) NPs with balanced, prominent magneto-optical properties. MNP@PPy NPs with an adjustable size, different shapes, and a controlled shell thickness were obtained using this method. The method was extended to synthesize other MNP-conjugated polymer core-shell NPs, such as MNP@polyaniline and MNP@poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS). We discuss the formation mechanism of the proposed method according to our experimental results. Finally, using the optical and magnetic properties of the obtained MNP@PEDOT:PSS NPs, in vivo multimodal imaging-guided hyperthermia was induced in mice, achieving an excellent tumor-ablation therapeutic effect. Our work is beneficial for extending the application of MNP-conjugated polymer core-shell NPs in the biomedical field.
关键词Iron Oxide Polypyrrole Photothermal Magnetic Hyperthermal Poly(3 4-ethylenedioxythiophene):Poly(4-styrenesulfonate) (Pedot:Pss)
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1007/s12274-016-1330-4
关键词[WOS]INFRARED PHOTOTHERMAL THERAPY ; IRON-OXIDE NANOPARTICLES ; IN-VIVO ; CANCER-THERAPY ; POLYPYRROLE NANOPARTICLES ; COMBINATION THERAPY ; FE5C2 NANOPARTICLES ; DRUG CARRIER ; PLATFORM ; NANOCOMPOSITES
收录类别SCI
语种英语
项目资助者Tsinghua University Initiative Scientific Research Program(20131089199) ; National Key Research and Development Program of China(2016YFB0700800) ; National Natural Science Foundation of China(81172182 ; 81671829)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000394322300029
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14393
专题中国科学院分子影像重点实验室
作者单位1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
2.Tsinghua Univ, Key Lab Adv Mat, Minist Educ China, Beijing 100084, Peoples R China
3.Tsinghua Univ, Engn Lab Functionalized Carbon Mat, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China
4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Yan, Hao,Zhao, Lingyun,Shang, Wenting,et al. General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics[J]. NANO RESEARCH,2017,10(2):704-717.
APA Yan, Hao.,Zhao, Lingyun.,Shang, Wenting.,Liu, Zhongqun.,Xie, Wensheng.,...&Kang, Feiyu.(2017).General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics.NANO RESEARCH,10(2),704-717.
MLA Yan, Hao,et al."General synthesis of high-performing magneto-conjugated polymer core-shell nanoparticles for multifunctional theranostics".NANO RESEARCH 10.2(2017):704-717.
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