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Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy
Sun, Mengmeng1; Peng, Don2; Hao, Hanjun1; Hu, Jin1; Wang, Dongliang3; Wang, Kun2; Liu, Jing1; Guo, Ximin4; Wei, Yen5; Gao, Weiping1
Source PublicationACS APPLIED MATERIALS & INTERFACES
2017-03-29
Volume9Issue:12Pages:10453-10460
SubtypeArticle
AbstractThe assembly of gold nanoparticles (AuNPs) to AuNP assemblies is of interest for cancer therapy and imaging. Herein we introduce a new and general paradigm, thermally triggered AuNP assembly, for the development of novel intelligent platforms for cancer photothermal therapy (PTT) and multimodal imaging. Site-specific conjugation of a thermally sensitive elastin-like polypeptide (ELP) to AuNPs yields thermally sensitive ELP-AuNPs. Interestingly, ELP-AuNPs can in situ form AuNP assemblies composed of short necklace-like gold nanostructures at elevated temperatures and thus show strong near-infrared light absorption and high photothermal effect. These thermally responsive properties of ELP-AuNPs enable simultaneous photothermal/photoacoustic/X-ray computed tomographic imaging and PTT of melanoma after single intratumoral injection of ELP-AuNPs. The thermally triggered assembly of a variety of nanoparticles with optical, electronic, and magnetic properties into nanoparticle assemblies may open new ways for the establishment of intelligent platforms for various applications in biomedicine.
KeywordGold Nanoparticle Elastin-like Polypeptide Photothermal Therapy Cancer Therapy Hyperthermia
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acsami.6b16408
WOS KeywordELASTIN-LIKE POLYPEPTIDES ; PH-INDUCED AGGREGATION ; TUMOR ACCUMULATION ; POLYMERS ; PHARMACOKINETICS ; NANOMEDICINE ; TRANSDUCTION ; RESONANCE ; RETENTION ; CHEMISTRY
Indexed BySCI
Language英语
Funding OrganizationBeijing Natural Science Foundation(2172028)
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000398246900017
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14419
Collection中国科学院分子影像重点实验室
Affiliation1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
4.Beijing Inst Basic Med Sci, Dept Adv Interdisciplinary Studies, Beijing 100850, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Sun, Mengmeng,Peng, Don,Hao, Hanjun,et al. Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(12):10453-10460.
APA Sun, Mengmeng.,Peng, Don.,Hao, Hanjun.,Hu, Jin.,Wang, Dongliang.,...&Gao, Weiping.(2017).Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,9(12),10453-10460.
MLA Sun, Mengmeng,et al."Thermally Triggered in Situ Assembly of Gold Nanoparticles for Cancer Multimodal Imaging and Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 9.12(2017):10453-10460.
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