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In vivo pentamodal tomographic imaging for small animals
Liu, Muhan1,2,3; Guo, Hongbo3,4; Liu, Hongbo1,2,3; Zhang, Zeyu3; Chi, Chongwei3; Hui, Hui3; Dong, Di3; Hu, Zhenhua3,5; Tian, Jie1,2,3,5
2017-03-01
发表期刊BIOMEDICAL OPTICS EXPRESS
卷号8期号:3页码:1356-1371
文章类型Article
摘要Multimodality molecular imaging emerges as a powerful strategy for correlating multimodal information. We developed a pentamodal imaging system which can perform positron emission tomography, bioluminescence tomography, fluorescence molecular tomography, Cerenkov luminescence tomography and X-ray computed tomography successively. Performance of sub-systems corresponding to different modalities were characterized. In vivo multimodal imaging of an orthotopic hepatocellular carcinoma xenograft mouse model was performed, and acquired multimodal images were fused. The feasibility of pentamodal tomographic imaging system was successfully validated with the imaging application on the mouse model. The ability of integrating anatomical, metabolic, and pharmacokinetic information promises applications of multimodality molecular imaging in precise medicine. (C) 2017 Optical Society of America.
关键词Pentamodal Tomographic Imaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1364/BOE.8.001356
关键词[WOS]BIOLUMINESCENCE TOMOGRAPHY ; CLINICAL-APPLICATIONS ; MRI ; DEVICES ; SYSTEM ; RECONSTRUCTION ; MODALITIES ; ALGORITHM ; SPECT/CT ; PLATFORM
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China (NSFC)(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 81527805 ; 61231004 ; 61622117 ; 81671759)
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000395942600007
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14427
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Northwest Univ Xian, Sch Informat Sci & Technol, Xian 710069, Peoples R China
5.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
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Liu, Muhan,Guo, Hongbo,Liu, Hongbo,et al. In vivo pentamodal tomographic imaging for small animals[J]. BIOMEDICAL OPTICS EXPRESS,2017,8(3):1356-1371.
APA Liu, Muhan.,Guo, Hongbo.,Liu, Hongbo.,Zhang, Zeyu.,Chi, Chongwei.,...&Tian, Jie.(2017).In vivo pentamodal tomographic imaging for small animals.BIOMEDICAL OPTICS EXPRESS,8(3),1356-1371.
MLA Liu, Muhan,et al."In vivo pentamodal tomographic imaging for small animals".BIOMEDICAL OPTICS EXPRESS 8.3(2017):1356-1371.
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