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Altered microstructure rather than morphology in the corpus callosum after lower limb amputation
Li, Zhichao1; Li, Chuanming1; Fan, Lingzhong2; Jiang, Guangyao1; Wu, Jixiang3; Jiang, Tianzi2; Yin, Xuntao1; Wang, Jian1
Source PublicationSCIENTIFIC REPORTS
2017-03-17
Volume7
SubtypeArticle
AbstractThe corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 age-and gender-matched normal controls were included. The CC was divided into five regions, and the area, thickness and diffusion parameters of each region were investigated. While morphometric analysis showed no significant differences between the two groups, amputees showed significant higher values in axial diffusivity, radial diffusivity and mean diffusivity in region II of the CC, which connects the bilateral premotor and supplementary motor areas. In contrast, the mean fractional anisotropy value of the fibers generated by these cortical areas, as measured by tractography, was significantly smaller in amputees. These results demonstrate that the interhemispheric pathways contributing to motor coordination and imagery are reorganized in lower limb amputees.
WOS HeadingsScience & Technology
DOI10.1038/srep44780
WOS KeywordPRIMARY MOTOR CORTEX ; WHITE-MATTER MICROSTRUCTURE ; PHANTOM LIMB ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; RADIAL DIFFUSIVITY ; BRAIN ACTIVATION ; PREMOTOR CORTEX ; SEX-DIFFERENCES ; PAIN
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China for Young Scholars(81301205) ; Open Project Program of the National Laboratory of Pattern Recognition (NLPR) in China(201306283)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000396834800001
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14431
Collection脑网络组研究中心
Affiliation1.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Third Mil Med Univ, Southwest Hosp, Dept Rehabil, Chongqing 400038, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhichao,Li, Chuanming,Fan, Lingzhong,et al. Altered microstructure rather than morphology in the corpus callosum after lower limb amputation[J]. SCIENTIFIC REPORTS,2017,7.
APA Li, Zhichao.,Li, Chuanming.,Fan, Lingzhong.,Jiang, Guangyao.,Wu, Jixiang.,...&Wang, Jian.(2017).Altered microstructure rather than morphology in the corpus callosum after lower limb amputation.SCIENTIFIC REPORTS,7.
MLA Li, Zhichao,et al."Altered microstructure rather than morphology in the corpus callosum after lower limb amputation".SCIENTIFIC REPORTS 7(2017).
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