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Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo
Zhan, Yonghua1; Cao, Xu1; Cao, Xin1; Li, Yingchao1; Tian, Jie2; Liang, Jimin1; Chen, Xueli1
Source PublicationJOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2017-02-01
Volume13Issue:2Pages:144-154
SubtypeArticle
AbstractIR-780 iodide, a near-infrared (NIR) fluorescent heptamethine dye, has attracted wide attention in the biomedical community. However, hydrophobicity and toxicity severely limit its further biomedical application. Although many successful efforts have been made to increase its solubility and biocompatibility, a strong fluorescent signal and longer retention time are in high demand in biomedical application in vivo as well as basic science research. In this work, we report the development of novel silica cross-linked micellar core-shell nanoparticles encapsulating IR-780 (NIR-Silica NPs) and their utility for biomedical imaging in vivo. Compared to free IR-780, the solubility of NIR-Silica NPs was not only greatly increased, but there was also a dramatic 5-7-fold enhancement of fluorescence intensity. More importantly, the exceptionally small size (25 nm) and colloidal stability of the NPs are also sufficient to realize the enhanced permeability and retention effect. In vitro cell viability assays further indicated that the NIR-Silica NPs are safer even at the highest concentration tested of 1.0 mg/mL. Finally, sentinel lymph node mapping and long-term tumor imaging in vivo demonstrated that the NIR-Silica NPs have a long circulation time and higher signal-to-noise ratio at a very low dye concentration and short exposure time (0.2 s). Therefore, the NIR-Silica NPs may be a promising fluorescence imaging agent for clinical application.
KeywordNear-infrared Heptamethine Dye Cross-linked Silica Fluorescence Optical Imaging
WOS HeadingsScience & Technology ; Technology
DOI10.1166/jbn.2017.2332
WOS KeywordBLOCK-COPOLYMER MICELLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; CANCER-THERAPY ; POLYMERIC MICELLES ; DYE ; AGENT ; VITRO
Indexed BySCI
Language英语
Funding OrganizationProgram of National Basic Research and Development Program of China (973)(2011CB707702) ; National Natural Science Foundation of China(81101100 ; Natural Science Basic Research Plan in Shaanxi Province of China(2015JQ6249) ; Fundamental Research Funds for the Central Universities(NSIZ021402 ; 81227901 ; NSIY061406) ; 81571725 ; 81230033 ; 81090272 ; 81101083 ; 31371006 ; 61405149 ; 81401442)
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS IDWOS:000397028800003
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Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14436
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhan, Yonghua,Cao, Xu,Cao, Xin,et al. Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(2):144-154.
APA Zhan, Yonghua.,Cao, Xu.,Cao, Xin.,Li, Yingchao.,Tian, Jie.,...&Chen, Xueli.(2017).Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(2),144-154.
MLA Zhan, Yonghua,et al."Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.2(2017):144-154.
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