CASIA OpenIR  > 中国科学院分子影像重点实验室
Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo
Zhan, Yonghua1; Cao, Xu1; Cao, Xin1; Li, Yingchao1; Tian, Jie2; Liang, Jimin1; Chen, Xueli1
2017-02-01
发表期刊JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷号13期号:2页码:144-154
文章类型Article
摘要IR-780 iodide, a near-infrared (NIR) fluorescent heptamethine dye, has attracted wide attention in the biomedical community. However, hydrophobicity and toxicity severely limit its further biomedical application. Although many successful efforts have been made to increase its solubility and biocompatibility, a strong fluorescent signal and longer retention time are in high demand in biomedical application in vivo as well as basic science research. In this work, we report the development of novel silica cross-linked micellar core-shell nanoparticles encapsulating IR-780 (NIR-Silica NPs) and their utility for biomedical imaging in vivo. Compared to free IR-780, the solubility of NIR-Silica NPs was not only greatly increased, but there was also a dramatic 5-7-fold enhancement of fluorescence intensity. More importantly, the exceptionally small size (25 nm) and colloidal stability of the NPs are also sufficient to realize the enhanced permeability and retention effect. In vitro cell viability assays further indicated that the NIR-Silica NPs are safer even at the highest concentration tested of 1.0 mg/mL. Finally, sentinel lymph node mapping and long-term tumor imaging in vivo demonstrated that the NIR-Silica NPs have a long circulation time and higher signal-to-noise ratio at a very low dye concentration and short exposure time (0.2 s). Therefore, the NIR-Silica NPs may be a promising fluorescence imaging agent for clinical application.
关键词Near-infrared Heptamethine Dye Cross-linked Silica Fluorescence Optical Imaging
WOS标题词Science & Technology ; Technology
DOI10.1166/jbn.2017.2332
关键词[WOS]BLOCK-COPOLYMER MICELLES ; INDOCYANINE GREEN ; DRUG-DELIVERY ; PHOTOTHERMAL THERAPY ; CANCER-THERAPY ; POLYMERIC MICELLES ; DYE ; AGENT ; VITRO
收录类别SCI
语种英语
项目资助者Program of National Basic Research and Development Program of China (973)(2011CB707702) ; National Natural Science Foundation of China(81101100 ; Natural Science Basic Research Plan in Shaanxi Province of China(2015JQ6249) ; Fundamental Research Funds for the Central Universities(NSIZ021402 ; 81227901 ; NSIY061406) ; 81571725 ; 81230033 ; 81090272 ; 81101083 ; 31371006 ; 61405149 ; 81401442)
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号WOS:000397028800003
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14436
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zhan, Yonghua,Cao, Xu,Cao, Xin,et al. Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2017,13(2):144-154.
APA Zhan, Yonghua.,Cao, Xu.,Cao, Xin.,Li, Yingchao.,Tian, Jie.,...&Chen, Xueli.(2017).Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,13(2),144-154.
MLA Zhan, Yonghua,et al."Silica Cross-Linked Micellar Core-Shell Nanoparticles Encapsulating IR-780 with Strong Bright and Good Biocompatibility for Optical Imaging In Vivo".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 13.2(2017):144-154.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhan, Yonghua]的文章
[Cao, Xu]的文章
[Cao, Xin]的文章
百度学术
百度学术中相似的文章
[Zhan, Yonghua]的文章
[Cao, Xu]的文章
[Cao, Xin]的文章
必应学术
必应学术中相似的文章
[Zhan, Yonghua]的文章
[Cao, Xu]的文章
[Cao, Xin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。