CASIA OpenIR  > 中国科学院分子影像重点实验室
Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography
Qian Liang; Jinzuo Ye; Yang Du; Chongwei Chi; Jie Tian
2017-03
Conference NameSPIE Medical Imaging. International Society for Optics and Photonics
Conference Date2017-02
Conference Place美国佛罗里达州奥兰多
Abstract

Hepatocellular carcinoma (HCC) is one of the most important leading causes of cancer-related deaths worldwide. In this study, we evaluated the efficacy of sorafenib on hepatocellular carcinoma through bioluminescence tomography (BLT) based on Micro-CT/BLT multi-modal system.

Initially, the human hepatocellular carcinoma cell line HepG2-Red-FLuc, which was transfected with luciferase gene, was cultured. And then, the orthotopic liver tumor mouse model was established on 4~5 weeks old athymic male Balb/c nude mice by inoculating the HepG2-Red-FLuc cell suspension into the liver lobe under isoflurane anesthesia. 15~20 days after tumor cells implantation, the mice were divided into two groups including the sorafenib treatment group and the control group. The mice in the treatment group were treated with sorafenib with dosage of 62 mg/kg/day by oral gavage for continuous 14 days, and the mice in the control group were treated with sterile water at equal volume. The tumor growth and drug treatment efficacy were dynamically monitored through BLT.

The results in this study showed that the growth of liver cancer can be dynamically monitored from very early stage, and also the sorafenib treatment efficacy can be reliably and objectively assessed using BLT imaging method. Our experimental result demonstrated sorafenib can inhibit the tumor growth effectively. BLT enabled the non-invasive and reliable assessment of anti-neoplastic drug efficacy on liver cancer.

Indexed ByEI
Document Type会议论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14488
Collection中国科学院分子影像重点实验室
Corresponding AuthorYang Du; Jie Tian
AffiliationKey Laboratory of Molecular Imaging of Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Qian Liang,Jinzuo Ye,Yang Du,et al. Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography[C],2017.
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