CASIA OpenIR  > 脑网络组研究中心
Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations
Wang, Tianqi1,2,3; Zhang, Xiaolong1,2; Li, Ang1,2,3; Zhu, Meifang1,2,3; Liu, Shu1,2,3; Qin, Wen5; Li, Jin1,2; Yu, Chunshui5; Jiang, Tianzi1,2,4,6,7; Liu, Bing1,2,4
Source PublicationNEUROIMAGE-CLINICAL
2017
Volume14Issue:14Pages:441-449
SubtypeArticle
AbstractMajor psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism (AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are highly heritable and polygenic. Evidence suggests that these five disorders have both shared and distinct genetic risks and neural connectivity abnormalities. To measure aggregate genetic risks, the polygenic risk score (PGRS) was computed. Two independent general populations (N = 360 and N = 323) were separately examined to investigate whether the cross-disorder PGRS and PGRS for a specific disorder were associated with individual variability in functional connectivity. Consistent altered functional connectivity was found with the bilateral insula: for the left supplementary motor area and the left superior temporal gyrus with the cross-disorder PGRS, for the left insula and right middle and superior temporal lobe associated with the PGRS for autism, for the bilateral midbrain, posterior cingulate, cuneus, and precuneus associated with the PGRS for BD, and for the left angular gyrus and the left dorsolateral prefrontal cortex associated with the PGRS for schizophrenia. No significant functional connectivity was found associated with the PGRS for ADHD and MDD. Our findings indicated that genetic effects on the cross-disorder and disorder-specific neural connectivity of common genetic risk loci are detectable in the general population. Our findings also indicated that polygenic risk contributes to the main neurobiological phenotypes of psychiatric disorders and that identifying cross-disorder and specific functional connectivity related to polygenic risks may elucidate the neural pathways for these disorders. (C) 2017 The Authors. Published by Elsevier Inc.
KeywordPolygenic Risk Score Neural Connectivity Cross-disorder Disorder-specific Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.02.011
WOS KeywordSTATE FUNCTIONAL CONNECTIVITY ; GENOME-WIDE ASSOCIATION ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DEFICIT HYPERACTIVITY DISORDER ; AUTISM SPECTRUM DISORDERS ; MAJOR DEPRESSIVE DISORDER ; BIPOLAR DISORDER ; GENERAL-POPULATION ; PREFRONTAL CORTEX ; BRAIN ACTIVATION
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Key Research and Development Program(2016YFC0904301) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301) ; Youth Innovation Promotion Association of Chinese Academy of Sciences
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000405984300047
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/14533
Collection脑网络组研究中心
Corresponding AuthorLiu, Bing
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Silence & Intelligence Techn, Beijing, Peoples R China
5.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tianqi,Zhang, Xiaolong,Li, Ang,et al. Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations[J]. NEUROIMAGE-CLINICAL,2017,14(14):441-449.
APA Wang, Tianqi.,Zhang, Xiaolong.,Li, Ang.,Zhu, Meifang.,Liu, Shu.,...&Liu, Bing.(2017).Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NEUROIMAGE-CLINICAL,14(14),441-449.
MLA Wang, Tianqi,et al."Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations".NEUROIMAGE-CLINICAL 14.14(2017):441-449.
Files in This Item: Download All
File Name/Size DocType Version Access License
polygenic risk for f(1182KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Tianqi]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Tianqi]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Tianqi]'s Articles
[Zhang, Xiaolong]'s Articles
[Li, Ang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.