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Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations
Wang, Tianqi1,2,3; Zhang, Xiaolong1,2; Li, Ang1,2,3; Zhu, Meifang1,2,3; Liu, Shu1,2,3; Qin, Wen5; Li, Jin1,2; Yu, Chunshui5; Jiang, Tianzi1,2,4,6,7; Liu, Bing1,2,4
2017
发表期刊NEUROIMAGE-CLINICAL
卷号14期号:14页码:441-449
文章类型Article
摘要Major psychiatric disorders, including attention deficit hyperactivity disorder (ADHD), autism (AUT), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SZ), are highly heritable and polygenic. Evidence suggests that these five disorders have both shared and distinct genetic risks and neural connectivity abnormalities. To measure aggregate genetic risks, the polygenic risk score (PGRS) was computed. Two independent general populations (N = 360 and N = 323) were separately examined to investigate whether the cross-disorder PGRS and PGRS for a specific disorder were associated with individual variability in functional connectivity. Consistent altered functional connectivity was found with the bilateral insula: for the left supplementary motor area and the left superior temporal gyrus with the cross-disorder PGRS, for the left insula and right middle and superior temporal lobe associated with the PGRS for autism, for the bilateral midbrain, posterior cingulate, cuneus, and precuneus associated with the PGRS for BD, and for the left angular gyrus and the left dorsolateral prefrontal cortex associated with the PGRS for schizophrenia. No significant functional connectivity was found associated with the PGRS for ADHD and MDD. Our findings indicated that genetic effects on the cross-disorder and disorder-specific neural connectivity of common genetic risk loci are detectable in the general population. Our findings also indicated that polygenic risk contributes to the main neurobiological phenotypes of psychiatric disorders and that identifying cross-disorder and specific functional connectivity related to polygenic risks may elucidate the neural pathways for these disorders. (C) 2017 The Authors. Published by Elsevier Inc.
关键词Polygenic Risk Score Neural Connectivity Cross-disorder Disorder-specific Fmri
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nicl.2017.02.011
关键词[WOS]STATE FUNCTIONAL CONNECTIVITY ; GENOME-WIDE ASSOCIATION ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; DEFICIT HYPERACTIVITY DISORDER ; AUTISM SPECTRUM DISORDERS ; MAJOR DEPRESSIVE DISORDER ; BIPOLAR DISORDER ; GENERAL-POPULATION ; PREFRONTAL CORTEX ; BRAIN ACTIVATION
收录类别SCI ; SSCI
语种英语
项目资助者National Key Research and Development Program(2016YFC0904301) ; Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91132301) ; Youth Innovation Promotion Association of Chinese Academy of Sciences
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000405984300047
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/14533
专题脑网络组研究中心
通讯作者Liu, Bing
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Silence & Intelligence Techn, Beijing, Peoples R China
5.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
7.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Sichuan, Peoples R China
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Wang, Tianqi,Zhang, Xiaolong,Li, Ang,et al. Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations[J]. NEUROIMAGE-CLINICAL,2017,14(14):441-449.
APA Wang, Tianqi.,Zhang, Xiaolong.,Li, Ang.,Zhu, Meifang.,Liu, Shu.,...&Liu, Bing.(2017).Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations.NEUROIMAGE-CLINICAL,14(14),441-449.
MLA Wang, Tianqi,et al."Polygenic risk for five psychiatric disorders and cross-disorder and disorder-specific neural connectivity in two independent populations".NEUROIMAGE-CLINICAL 14.14(2017):441-449.
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