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Fast in vivo bioluminescence tomography using a novel pure optical imaging technique
Zhang, Shuang1; Leng, Chengcai2; Liu, Hongbo2; Wang, Kun2; Tian, Jie2
Source PublicationJOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
2017-05-01
Volume10Issue:3
SubtypeArticle
AbstractBioluminescence tomography (BLT) is a novel optical molecular imaging technique that advanced the conventional planar bioluminescence imaging (BLI) into a quantifiable three-dimensional (3D) approach in preclinical living animal studies in oncology. In order to solve the inverse problem and reconstruct tumor lesions inside animal body accurately, the prior structural information is commonly obtained from X-ray computed tomography (CT). This strategy requires a complicated hybrid imaging system, extensive post imaging analysis and involvement of ionizing radiation. Moreover, the overall robustness highly depends on the fusion accuracy between the optical and structural information. Here, we present a pure optical bioluminescence tomographic (POBT) system and a novel BLT workflow based on multi-view projection acquisition and 3D surface reconstruction. This method can reconstruct the 3D surface of an imaging subject based on a sparse set of planar white-light and bioluminescent images, so that the prior structural information can be offered for 3D tumor lesion reconstruction without the involvement of CT. The performance of this novel technique was evaluated through the comparison with a conventional dual-modality tomographic (DMT) system and a commercialized optical imaging system (IVIS Spectrum) using three breast cancer xenografts. The results revealed that the new technique offered comparable in vivo tomographic accuracy with the DMT system (P > 0.05) in much shorter data analysis time. It also offered significantly better accuracy comparing with the IVIS system (P < 0.04) without sacrificing too much time.
KeywordOptical Surface Reconstruction Bioluminescence Tomography Reconstruction Optical Molecular Imaging Light Flux Reconstruction
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1142/S1793545817500031
WOS KeywordRECONSTRUCTION ; MOUSE ; MODEL
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; Scientific Research and Equipment Development Project of the Chinese Academy of Sciences(YZ201359) ; Key Research Program of the Chinese Academy of Sciences(KGZD-EW-T03) ; Chinese Academy of Sciences Fellowship for Young International Scientists(2013Y1GA0004) ; China Postdoctoral Science Foundation(2014M550881 ; 61231004 ; 2015T80155) ; 81527805 ; 61401462)
WOS Research AreaOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000399088400008
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15087
Collection中国科学院分子影像重点实验室
Affiliation1.Northeastern Univ, Sinodutch Biomed & Informat Engn Sch, Shenyang 110819, Peoples R China
2.Chinese Acad Sci, Key Lab Mol Imaging, Zhongguancun East Rd 95, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Shuang,Leng, Chengcai,Liu, Hongbo,et al. Fast in vivo bioluminescence tomography using a novel pure optical imaging technique[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2017,10(3).
APA Zhang, Shuang,Leng, Chengcai,Liu, Hongbo,Wang, Kun,&Tian, Jie.(2017).Fast in vivo bioluminescence tomography using a novel pure optical imaging technique.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,10(3).
MLA Zhang, Shuang,et al."Fast in vivo bioluminescence tomography using a novel pure optical imaging technique".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 10.3(2017).
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