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Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain
Wu, Tong1; Grandjean, Joanes2,3,7; Bosshard, Simone C.4; Rudin, Markus2,3; Reutens, David4; Jiang, Tianzi1,5,6
Source PublicationNEUROIMAGE
2017-04-01
Volume149Pages:190-199
SubtypeArticle
AbstractStudies in mice using resting-state functional magnetic resonance imaging (rs-fMRI) have provided opportunities to investigate the effects of pharmacological manipulations on brain function and map the phenotypes of mouse models of human brain disorders. Mouse rs-fMRI is typically performed under anaesthesia, which induces both regional suppression of brain activity and disruption of large-scale neural networks. Previous comparative studies using rodents investigating various drug effects on long-distance functional connectivity (FC) have reported agent-specific FC patterns, however, effects of regional suppression are sparsely explored. Here we examined changes in regional connectivity under six different anaesthesia conditions using mouse rsfMRI with the goal of refining the framework of understanding the brain activation under anaesthesia at a local level. Regional homogeneity (ReHo) was used to map local synchronization in the brain, followed by analysis of several brain areas based on ReHo maps. The results revealed high local coherence in most brain areas. The primary somatosensory cortex and caudate-putamen showed agent-specific properties. Lower local coherence in the cingulate cortex was observed under medetomidine, particularly when compared to the combination of medetomidine and isoflurane. The thalamus was associated with retained local coherence across anaesthetic levels and multiple nuclei. These results show that anaesthesia induced by the investigated anaesthetics through different molecular targets promote agent-specific regional connectivity. In addition, ReHo is a data-driven method with minimum user interaction, easy to use and fast to compute. Given that examination of the brain at a local level is widely applied in human rs-fMRI studies, our results show its sensitivity to extract information on varied neuronal activity under six different regimens relevant to mouse functional imaging. These results, therefore, will inform future rs-fMRI studies on mice and the type of anaesthetic agent used, and will help to bridge observations between this burgeoning research field and ongoing human research across analytical scales.
KeywordResting State Fmri Mouse Anaesthesia Regional Homogeneity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.neuroimage.2017.01.074
WOS KeywordRESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; ABNORMAL NEURAL ACTIVITY ; AWAKE RAT-BRAIN ; FUNCTIONAL CONNECTIVITY ; GENERAL-ANESTHESIA ; CEREBRAL AMYLOIDOSIS ; ALZHEIMERS-DISEASE ; RECEPTOR AGONIST ; MRI ATLAS
Indexed BySCI
Language英语
Funding OrganizationQueensland Brain Institute and Centre for Advanced Imaging at the University of Queensland
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000399438500016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15093
Collection脑网络组研究中心
Affiliation1.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
2.Univ Zurich, Inst Biomed Engn, Mol Imaging & Funct Pharmacol, Zurich, Switzerland
3.ETH, Zurich, Switzerland
4.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 625014, Peoples R China
7.Agcy Sci Technol & Res, Singapore Biolmaging Consortium, Singapore, Singapore
Recommended Citation
GB/T 7714
Wu, Tong,Grandjean, Joanes,Bosshard, Simone C.,et al. Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain[J]. NEUROIMAGE,2017,149:190-199.
APA Wu, Tong,Grandjean, Joanes,Bosshard, Simone C.,Rudin, Markus,Reutens, David,&Jiang, Tianzi.(2017).Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain.NEUROIMAGE,149,190-199.
MLA Wu, Tong,et al."Altered regional connectivity reflecting effects of different anaesthesia protocols in the mouse brain".NEUROIMAGE 149(2017):190-199.
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