CASIA OpenIR  > 中国科学院分子影像重点实验室
Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes
Xia, Yuqiong1; Zhang, Ruili1; Wang, Zhongliang1; Tian, Jie1,2; Chen, Xiaoyuan3
Source PublicationCHEMICAL SOCIETY REVIEWS
2017-05-21
Volume46Issue:10Pages:2824-2843
SubtypeReview
AbstractRNA plays an important role in life processes. Imaging of messenger RNAs (mRNAs) and micro-RNAs (miRNAs) not only allows us to learn the formation and transcription of mRNAs and the biogenesis of miRNAs involved in various life processes, but also helps in detecting cancer. High-performance RNA imaging probes greatly expand our view of life processes and enhance the cancer detection accuracy. In this review, we summarize the state-of-the-art high-performance RNA imaging probes, including exogenous probes that can image RNA sequences with special modification and endogeneous probes that can directly image endogenous RNAs without special treatment. For each probe, we review its structure and imaging principle in detail. Finally, we summarize the application of mRNA and miRNA imaging probes in studying life processes as well as in detecting cancer. By correlating the structures and principles of various probes with their practical uses, we compare different RNA imaging probes and offer guidance for better utilization of the current imaging probes and the future design of higher-performance RNA imaging probes.
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c6cs00675b
WOS KeywordIN-SITU HYBRIDIZATION ; ENHANCED-RAMAN-SPECTROSCOPY ; ROLLING CIRCLE AMPLIFICATION ; MULTIPLE MESSENGER-RNAS ; LIVING BACTERIAL-CELLS ; DNA MOLECULAR BEACONS ; LIVE CELLS ; GENE-EXPRESSION ; GOLD NANOPARTICLES ; MICRORNA BIOGENESIS
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81671753 ; national 1000 Young Talents Program of China ; Fundamental Research Funds for the Central universities(JB161202) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) ; 81501524)
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000401905400008
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Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15114
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Imaging & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
Recommended Citation
GB/T 7714
Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,et al. Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes[J]. CHEMICAL SOCIETY REVIEWS,2017,46(10):2824-2843.
APA Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,Tian, Jie,&Chen, Xiaoyuan.(2017).Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes.CHEMICAL SOCIETY REVIEWS,46(10),2824-2843.
MLA Xia, Yuqiong,et al."Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes".CHEMICAL SOCIETY REVIEWS 46.10(2017):2824-2843.
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