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Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes
Xia, Yuqiong1; Zhang, Ruili1; Wang, Zhongliang1; Tian, Jie1,2; Chen, Xiaoyuan3
2017-05-21
发表期刊CHEMICAL SOCIETY REVIEWS
卷号46期号:10页码:2824-2843
文章类型Review
摘要RNA plays an important role in life processes. Imaging of messenger RNAs (mRNAs) and micro-RNAs (miRNAs) not only allows us to learn the formation and transcription of mRNAs and the biogenesis of miRNAs involved in various life processes, but also helps in detecting cancer. High-performance RNA imaging probes greatly expand our view of life processes and enhance the cancer detection accuracy. In this review, we summarize the state-of-the-art high-performance RNA imaging probes, including exogenous probes that can image RNA sequences with special modification and endogeneous probes that can directly image endogenous RNAs without special treatment. For each probe, we review its structure and imaging principle in detail. Finally, we summarize the application of mRNA and miRNA imaging probes in studying life processes as well as in detecting cancer. By correlating the structures and principles of various probes with their practical uses, we compare different RNA imaging probes and offer guidance for better utilization of the current imaging probes and the future design of higher-performance RNA imaging probes.
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c6cs00675b
关键词[WOS]IN-SITU HYBRIDIZATION ; ENHANCED-RAMAN-SPECTROSCOPY ; ROLLING CIRCLE AMPLIFICATION ; MULTIPLE MESSENGER-RNAS ; LIVING BACTERIAL-CELLS ; DNA MOLECULAR BEACONS ; LIVE CELLS ; GENE-EXPRESSION ; GOLD NANOPARTICLES ; MICRORNA BIOGENESIS
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81671753 ; national 1000 Young Talents Program of China ; Fundamental Research Funds for the Central universities(JB161202) ; Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) ; 81501524)
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000401905400008
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15114
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol Imaging & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA
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Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,et al. Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes[J]. CHEMICAL SOCIETY REVIEWS,2017,46(10):2824-2843.
APA Xia, Yuqiong,Zhang, Ruili,Wang, Zhongliang,Tian, Jie,&Chen, Xiaoyuan.(2017).Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes.CHEMICAL SOCIETY REVIEWS,46(10),2824-2843.
MLA Xia, Yuqiong,et al."Recent advances in high-performance fluorescent and bioluminescent RNA imaging probes".CHEMICAL SOCIETY REVIEWS 46.10(2017):2824-2843.
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