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Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study
Li, Yangding1,2; Yuan, Kai1,2; Bi, Yanzhi1,2; Guan, Yanyan1,2; Cheng, Jiadong1,2; Zhang, Yajuan1,2; Shi, Sha1,2; Lu, Xiaoqi3; Yu, Dahua3; Tian, Jie1,2,4
Source PublicationBRAIN IMAGING AND BEHAVIOR
2017-06-01
Volume11Issue:3Pages:677-684
SubtypeArticle
AbstractStudying the neural correlates of craving to smoke in young adulthood is of great importance to improve treatment outcomes in nicotine dependence. Previous nicotine dependence studies mainly focused on the neural substrates of craving elicited by smoking-related cues. More explicit attention to abstinence-induced craving during resting state in nicotine dependence has the potential to yield valuable information about craving, and characterizing this kind of craving is critical for developing effective interventions. Twenty-five young male smokers were enrolled in the present study. A within-subject experiment design was carried out to compare regional homogeneity (ReHo) between 12-h smoking abstinence and smoking satiety conditions during resting state in young adult smokers. Then, the ReHo changes associated with smoking abstinence (compared with satiety) were further examined for correlations with abstinence-induced changes in subjective craving. We found young adult smokers in abstinence state (compared with satiety) had higher ReHo in brain regions in fronto-striatal circuits including bilateral caudate, anterior cingulate cortex (ACC) and bilateral dorsal lateral prefrontal cortex (DLPFC), as well as brain regions in default mode network (DMN) including posterior cingulate cortex (PCC)/precuneus and angular gyrus. Additionally, we found the ReHo changes of the ACC and the bilateral caudate were positively correlated with the changes in craving induced by abstinence (i.e., abstinence minus satiety) in young adult smokers. The present findings improve the understanding of the effects of acute smoking abstinence on spontaneous brain activity and may contribute new insights into the neural mechanism of abstinence-induced craving in nicotine dependence.
KeywordResting State Within-subject Design Regional Homogeneity (Reho) Abstinence-induced Craving Young Adult Smokers
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9544-3
WOS KeywordTRANSCRANIAL MAGNETIC STIMULATION ; NICOTINIC ACETYLCHOLINE-RECEPTORS ; REGIONAL HOMOGENEITY CHANGES ; GRAY-MATTER VOLUMES ; CIGARETTE-SMOKING ; FUNCTIONAL CONNECTIVITY ; ALZHEIMERS-DISEASE ; COGNITIVE CONTROL ; DORSAL STRIATUM ; DEFAULT MODE
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; China Post-doctoral Science Foundation(2014M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 81470816 ; 81471737 ; 81301281 ; 81271546 ; 81271549)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000403676400007
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15232
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Inner Mongolia Key Lab Pattern Recognit & Intelli, Baotou 014010, Inner Mongolia, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, Yangding,Yuan, Kai,Bi, Yanzhi,et al. Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(3):677-684.
APA Li, Yangding.,Yuan, Kai.,Bi, Yanzhi.,Guan, Yanyan.,Cheng, Jiadong.,...&Tian, Jie.(2017).Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study.BRAIN IMAGING AND BEHAVIOR,11(3),677-684.
MLA Li, Yangding,et al."Neural correlates of 12-h abstinence-induced craving in young adult smokers: a resting-state study".BRAIN IMAGING AND BEHAVIOR 11.3(2017):677-684.
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