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Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Xu, Bing1; Zhang, Yu1,2; Du, Xu-Fei1; Li, Jia1; Zi, Hua-Xing1,2; Bu, Ji-Wen1; Yan, Yong1,3; Han, Hua4; Du, Jiu-Lin1,2,3
Source PublicationCELL RESEARCH
2017-07-01
Volume27Issue:7Pages:882-897
SubtypeArticle
AbstractVascular integrity helps maintain brain microenvironment homeostasis, which is critical for the normal development and function of the central nervous system. It is known that neural cells can regulate brain vascular integrity. However, due to the high complexity of neurovascular interactions involved, understanding of the neural regulation of brain vascular integrity is still rudimentary. Using intact zebrafish larvae and cultured rodent brain cells, we find that neurons transfer miR-132, a highly conserved and neuron-enriched microRNA, via secreting exosomes to endothelial cells (ECs) to maintain brain vascular integrity. Following translocation to ECs through exosome internalization, miR-132 regulates the expression of vascular endothelial cadherin (VE-cadherin), an important adherens junction protein, by directly targeting eukaryotic elongation factor 2 kinase (eef2k). Disruption of neuronal miR-132 expression or exosome secretion, or overexpression of vascular eef2k impairs VE-cadherin expression and brain vascular integrity. Our study indicates that miR-132 acts as an intercellular signal mediating neural regulation of the brain vascular integrity and suggests that the neuronal exosome is a novel avenue for neurovascular communication.
KeywordBrain Vascular Integrity Neuron Endothelial Cell Exosome Mir-132 Eef2k Zebrafish
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1038/cr.2017.62
WOS KeywordFACTOR 2 KINASE ; EXTRACELLULAR VESICLES ; NERVOUS-SYSTEM ; BARRIER INTEGRITY ; VE-CADHERIN ; CELL ; ZEBRAFISH ; MICRORNA ; ANGIOGENESIS ; MIR-132
Indexed BySCI
Language英语
Funding OrganizationKey State Research Program of China(2012CB945101) ; National Natural Science Foundation of China(31325011 ; China Wan-Ren Program ; Shanghai Leading Talent Program ; Shanghai Subject Chief Scientist Program(14XD1404100) ; Yang-Fan Program from the Science and Technology Commission of Shanghai Municipality(14YF1406600) ; Postdoctoral Research Foundation of China(2015T80458) ; 31500849)
WOS Research AreaCell Biology
WOS SubjectCell Biology
WOS IDWOS:000404618500007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15242
Collection类脑智能研究中心
Affiliation1.Chinese Acad Sci, Inst Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
2.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China
4.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, 95 Zhong Guan Cun East Rd, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Bing,Zhang, Yu,Du, Xu-Fei,et al. Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity[J]. CELL RESEARCH,2017,27(7):882-897.
APA Xu, Bing.,Zhang, Yu.,Du, Xu-Fei.,Li, Jia.,Zi, Hua-Xing.,...&Du, Jiu-Lin.(2017).Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity.CELL RESEARCH,27(7),882-897.
MLA Xu, Bing,et al."Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity".CELL RESEARCH 27.7(2017):882-897.
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