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Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens
Xia, Xiaoluan1; Fan, Lingzhong2; Cheng, Chen1; Eickhoff, Simon B.4,5; Chen, Junjie1; Li, Haifang1; Jiang, Tianzi2,3,6,7
Source PublicationHUMAN BRAIN MAPPING
2017-08-01
Volume38Issue:8Pages:3878-3898
SubtypeReview
AbstractThe subdifferentiation of the nucleus accumbens (NAc) has been extensively studied using neuroanatomy and histochemistry, yielding a well-accepted dichotomic shell/core architecture that reflects dissociable roles, such as in reward and aversion, respectively. However, in vivo parcellation of these structures in humans has been rare, potentially impairing future research into the structural and functional characteristics and alterations of putative NAc subregions. Here, we used three complementary parcellation schemes based on tractography, task-independent functional connectivity, and task-dependent co-activation to investigate the regional differentiation within the NAc. We found that a 2-cluster solution with shell-like and core-like subdivisions provided the best description of the data and was consistent with the earlier anatomical shell/core architecture. The consensus clusters from this optimal solution, which was based on the three schemes, were used as the final parcels for the subsequent connection analyses. The resulting connectivity patterns presented inter-hemispheric symmetry, convergence and divergence across the modalities, and, most importantly, clearly distinct patterns between the two subregions. This convergent connectivity patterns also confirmed the connections in animal models, supporting views that the two subregions could have antagonistic roles in some circumstances. Finally, the identified parcels should be helpful in further neuroimaging studies of the NAc. Hum Brain Mapp 38:3878-3898, 2017. (c) 2017 Wiley Periodicals, Inc.
KeywordNucleus Accumbens Connectivity-based Parcellation Tractography Functional Connectivity Meta-analytic Connectivity Modeling
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.23636
WOS KeywordHUMAN CONNECTOME PROJECT ; ANTERIOR CINGULATE CORTEX ; INFERIOR PARIETAL LOBULE ; DEEP BRAIN-STIMULATION ; CONVERGENT FUNCTIONAL ARCHITECTURE ; INFRALIMBIC PREFRONTAL CORTEX ; VENTRAL TEGMENTAL AREA ; HUMAN FRONTAL POLE ; BASAL GANGLIA ; ORBITOFRONTAL CORTEX
Indexed BySCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973)(2011CB707801 ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91432302 ; Deutsche Forschungsgemeinschaft(EI 816/4-1 ; National Institute of Mental Health(R01-MH074457) ; Helmholtz Portfolio Theme "Supercomputing and Modeling for the Human Brain" ; European Union Seventh Framework Programme(604102) ; Beijing Municipal Science & Technology Commission(Z161100000216139) ; 2012CB720702) ; 91132301 ; EI 816/6-1) ; 81501179 ; 81270020 ; 61373101 ; 61472270 ; 61402318)
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000404963900009
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15248
Collection脑网络组研究中心
Affiliation1.Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030600, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Res Ctr Juelich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany
5.Heinrich Heine Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, D-40225 Dusseldorf, Germany
6.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China
7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
Recommended Citation
GB/T 7714
Xia, Xiaoluan,Fan, Lingzhong,Cheng, Chen,et al. Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens[J]. HUMAN BRAIN MAPPING,2017,38(8):3878-3898.
APA Xia, Xiaoluan.,Fan, Lingzhong.,Cheng, Chen.,Eickhoff, Simon B..,Chen, Junjie.,...&Jiang, Tianzi.(2017).Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens.HUMAN BRAIN MAPPING,38(8),3878-3898.
MLA Xia, Xiaoluan,et al."Multimodal connectivity-based parcellation reveals a shell-core dichotomy of the human nucleus accumbens".HUMAN BRAIN MAPPING 38.8(2017):3878-3898.
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