Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
Liu, Yue1; Wang, Jieqiong2,3; Zhang, Jishui4; Wen, Hongwei2,3; Zhang, Yue1; Kang, Huiying1; Wang, Xu4; Li, Wenfeng1; He, Huiguang2,3,5; Peng, Yun1
2017-07-06
发表期刊SCIENTIFIC REPORTS
卷号7
文章类型Article
摘要Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naive and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.
WOS标题词Science & Technology
DOI10.1038/s41598-017-04148-z
关键词[WOS]ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; OLD-WORLD MONKEY ; FUNCTIONAL CONNECTIVITY ; BASAL GANGLIA ; REGIONAL HOMOGENEITY ; TIC DISORDERS ; NETWORKS ; MRI ; ABNORMALITIES ; INSULA
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81671651 ; Youth Innovation Promotion Association CAS ; Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; Beijing health system top level health technical personnel training plan(2015-3-082) ; Beijing Municipal Science and Technology Project Support(Z161100000116050) ; 91520202)
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000404841100064
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15253
专题复杂系统管理与控制国家重点实验室_影像分析与机器视觉
作者单位1.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Natl Ctr Childrens Hlth, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Natl Ctr Childrens Hlth, Beijing, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
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Liu, Yue,Wang, Jieqiong,Zhang, Jishui,et al. Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yue.,Wang, Jieqiong.,Zhang, Jishui.,Wen, Hongwei.,Zhang, Yue.,...&Peng, Yun.(2017).Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.SCIENTIFIC REPORTS,7.
MLA Liu, Yue,et al."Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study".SCIENTIFIC REPORTS 7(2017).
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