Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study
Liu, Yue1; Wang, Jieqiong2,3; Zhang, Jishui4; Wen, Hongwei2,3; Zhang, Yue1; Kang, Huiying1; Wang, Xu4; Li, Wenfeng1; He, Huiguang2,3,5; Peng, Yun1
Source PublicationSCIENTIFIC REPORTS
2017-07-06
Volume7
SubtypeArticle
AbstractTourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated the alterations of spontaneous brain activities in children with TS by resting-state functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 21 drug-naive and pure TS children and 29 demographically matched healthy children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to measure spontaneous brain activity. We found significant alterations of ALFF or fALFF in vision-related structures including the calcarine sulcus, the cuneus, the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found in the right cerebellum. Further analysis showed that the ReHo value of the right cerebellum was positively correlated with TS duration. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the neurophysiological mechanism in TS children. Moreover, the right cerebellum can be potentially used as a biomarker for the pathophysiology of early TS in children.
WOS HeadingsScience & Technology
DOI10.1038/s41598-017-04148-z
WOS KeywordATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; OLD-WORLD MONKEY ; FUNCTIONAL CONNECTIVITY ; BASAL GANGLIA ; REGIONAL HOMOGENEITY ; TIC DISORDERS ; NETWORKS ; MRI ; ABNORMALITIES ; INSULA
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81671651 ; Youth Innovation Promotion Association CAS ; Beijing Municipal Administration of Hospitals Incubating Program(PX2016035) ; Beijing health system top level health technical personnel training plan(2015-3-082) ; Beijing Municipal Science and Technology Project Support(Z161100000116050) ; 91520202)
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000404841100064
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15253
Collection复杂系统管理与控制国家重点实验室_影像分析与机器视觉
Affiliation1.Capital Med Univ, Beijing Childrens Hosp, Dept Radiol, Natl Ctr Childrens Hlth, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Capital Med Univ, Beijing Childrens Hosp, Dept Neurol, Natl Ctr Childrens Hlth, Beijing, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yue,Wang, Jieqiong,Zhang, Jishui,et al. Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yue.,Wang, Jieqiong.,Zhang, Jishui.,Wen, Hongwei.,Zhang, Yue.,...&Peng, Yun.(2017).Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study.SCIENTIFIC REPORTS,7.
MLA Liu, Yue,et al."Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a Resting-state fMRI Study".SCIENTIFIC REPORTS 7(2017).
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