| Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery | |
Mao, Yamin1,2,3 ; Wang, Kun1,2; He, Kunshan1,2,3; Ye, Jinzuo1,2,3; Yang, Fan4; Zhou, Jian4; Li, Hao4; Chen, Xiuyuan4; Wang, Jun; Chi, Chongwei1,2; Tian, Jie1,2
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| 发表期刊 | JOURNAL OF BIOMEDICAL OPTICS
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| 2017-06-01 | |
| 卷号 | 22期号:6 |
| 文章类型 | Article |
| 摘要 | In minimally invasive surgery, the white-light thoracoscope as a standard imaging tool is facing challenges of the low contrast between important anatomical or pathological regions and surrounding tissues. Recently, the near-infrared (NIR) fluorescence imaging shows superior advantages over the conventional white-light observation, which inspires researchers to develop imaging systems to improve overall outcomes of endoscopic imaging. We developed an NIR and white-light dual-channel thoracoscope system, which achieved high-fluorescent signal acquisition efficiency and the simultaneously optimal visualization of the NIR and color dual-channel signals. The system was designed to have fast and accurate image registration and high signal-to-background ratio by optimizing both software algorithms and optical hardware components for better performance in the NIR spectrum band. The system evaluation demonstrated that the minimally detectable concentration of indocyanine green (ICG) was 0.01 mu M, and the spatial resolution was 35 mu m. The in vivo feasibility of our system was verified by the preclinical experiments using six porcine models with the intravenous injection of ICG. Furthermore, the system was successfully applied for guiding the minimally invasive segmentectomy in three lung cancer patients, which revealed that our system held great promise for the clinical translation in lung cancer surgeries. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| 关键词 | Fluorescence Image-guided Surgery Minimally Invasive Surgery Thoracoscope Indocyanine Green Lung Cancer Surgery Thoracic Duct Pulmonary Segments |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| DOI | 10.1117/1.JBO.22.6.066002 |
| 关键词[WOS] | INDOCYANINE GREEN ; FLUORESCENCE ENDOSCOPY ; GUIDED SURGERY ; REAL-TIME ; SEGMENTECTOMY ; IDENTIFICATION ; DUCT ; DISSECTION ; RESECTION ; SURVIVAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(YZ201359 ; Institutional Ethics Committee of Peking University People's Hospital(2015PHB157-01 ; 81527805 ; KGZD-EW-T03) ; NCT02611245) ; 81501594 ; 61671449 ; 61231004 ; 61501462) |
| WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS记录号 | WOS:000405436800012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/15257 |
| 专题 | 中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mao, Yamin,Wang, Kun,He, Kunshan,et al. Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery[J]. JOURNAL OF BIOMEDICAL OPTICS,2017,22(6). |
| APA | Mao, Yamin.,Wang, Kun.,He, Kunshan.,Ye, Jinzuo.,Yang, Fan.,...&Tian, Jie.(2017).Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery.JOURNAL OF BIOMEDICAL OPTICS,22(6). |
| MLA | Mao, Yamin,et al."Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery".JOURNAL OF BIOMEDICAL OPTICS 22.6(2017). |
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