CASIA OpenIR  > 中国科学院分子影像重点实验室
Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery
Mao, Yamin1,2,3; Wang, Kun1,2; He, Kunshan1,2,3; Ye, Jinzuo1,2,3; Yang, Fan4; Zhou, Jian4; Li, Hao4; Chen, Xiuyuan4; Wang, Jun; Chi, Chongwei1,2; Tian, Jie1,2
2017-06-01
发表期刊JOURNAL OF BIOMEDICAL OPTICS
卷号22期号:6
文章类型Article
摘要In minimally invasive surgery, the white-light thoracoscope as a standard imaging tool is facing challenges of the low contrast between important anatomical or pathological regions and surrounding tissues. Recently, the near-infrared (NIR) fluorescence imaging shows superior advantages over the conventional white-light observation, which inspires researchers to develop imaging systems to improve overall outcomes of endoscopic imaging. We developed an NIR and white-light dual-channel thoracoscope system, which achieved high-fluorescent signal acquisition efficiency and the simultaneously optimal visualization of the NIR and color dual-channel signals. The system was designed to have fast and accurate image registration and high signal-to-background ratio by optimizing both software algorithms and optical hardware components for better performance in the NIR spectrum band. The system evaluation demonstrated that the minimally detectable concentration of indocyanine green (ICG) was 0.01 mu M, and the spatial resolution was 35 mu m. The in vivo feasibility of our system was verified by the preclinical experiments using six porcine models with the intravenous injection of ICG. Furthermore, the system was successfully applied for guiding the minimally invasive segmentectomy in three lung cancer patients, which revealed that our system held great promise for the clinical translation in lung cancer surgeries. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
关键词Fluorescence Image-guided Surgery Minimally Invasive Surgery Thoracoscope Indocyanine Green Lung Cancer Surgery Thoracic Duct Pulmonary Segments
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.22.6.066002
关键词[WOS]INDOCYANINE GREEN ; FLUORESCENCE ENDOSCOPY ; GUIDED SURGERY ; REAL-TIME ; SEGMENTECTOMY ; IDENTIFICATION ; DUCT ; DISSECTION ; RESECTION ; SURVIVAL
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(YZ201359 ; Institutional Ethics Committee of Peking University People's Hospital(2015PHB157-01 ; 81527805 ; KGZD-EW-T03) ; NCT02611245) ; 81501594 ; 61671449 ; 61231004 ; 61501462)
WOS研究方向Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000405436800012
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15257
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Mao, Yamin,Wang, Kun,He, Kunshan,et al. Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery[J]. JOURNAL OF BIOMEDICAL OPTICS,2017,22(6).
APA Mao, Yamin.,Wang, Kun.,He, Kunshan.,Ye, Jinzuo.,Yang, Fan.,...&Tian, Jie.(2017).Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery.JOURNAL OF BIOMEDICAL OPTICS,22(6).
MLA Mao, Yamin,et al."Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery".JOURNAL OF BIOMEDICAL OPTICS 22.6(2017).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Development and appl(2280KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Mao, Yamin]的文章
[Wang, Kun]的文章
[He, Kunshan]的文章
百度学术
百度学术中相似的文章
[Mao, Yamin]的文章
[Wang, Kun]的文章
[He, Kunshan]的文章
必应学术
必应学术中相似的文章
[Mao, Yamin]的文章
[Wang, Kun]的文章
[He, Kunshan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Development and application of the.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。