CASIA OpenIR  > 中国科学院分子影像重点实验室
Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery
Mao, Yamin1,2,3; Wang, Kun1,2; He, Kunshan1,2,3; Ye, Jinzuo1,2,3; Yang, Fan4; Zhou, Jian4; Li, Hao4; Chen, Xiuyuan4; Wang, Jun; Chi, Chongwei1,2; Tian, Jie1,2
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
2017-06-01
Volume22Issue:6
SubtypeArticle
AbstractIn minimally invasive surgery, the white-light thoracoscope as a standard imaging tool is facing challenges of the low contrast between important anatomical or pathological regions and surrounding tissues. Recently, the near-infrared (NIR) fluorescence imaging shows superior advantages over the conventional white-light observation, which inspires researchers to develop imaging systems to improve overall outcomes of endoscopic imaging. We developed an NIR and white-light dual-channel thoracoscope system, which achieved high-fluorescent signal acquisition efficiency and the simultaneously optimal visualization of the NIR and color dual-channel signals. The system was designed to have fast and accurate image registration and high signal-to-background ratio by optimizing both software algorithms and optical hardware components for better performance in the NIR spectrum band. The system evaluation demonstrated that the minimally detectable concentration of indocyanine green (ICG) was 0.01 mu M, and the spatial resolution was 35 mu m. The in vivo feasibility of our system was verified by the preclinical experiments using six porcine models with the intravenous injection of ICG. Furthermore, the system was successfully applied for guiding the minimally invasive segmentectomy in three lung cancer patients, which revealed that our system held great promise for the clinical translation in lung cancer surgeries. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
KeywordFluorescence Image-guided Surgery Minimally Invasive Surgery Thoracoscope Indocyanine Green Lung Cancer Surgery Thoracic Duct Pulmonary Segments
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
DOI10.1117/1.JBO.22.6.066002
WOS KeywordINDOCYANINE GREEN ; FLUORESCENCE ENDOSCOPY ; GUIDED SURGERY ; REAL-TIME ; SEGMENTECTOMY ; IDENTIFICATION ; DUCT ; DISSECTION ; RESECTION ; SURVIVAL
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; Chinese Academy of Sciences(YZ201359 ; Institutional Ethics Committee of Peking University People's Hospital(2015PHB157-01 ; 81527805 ; KGZD-EW-T03) ; NCT02611245) ; 81501594 ; 61671449 ; 61231004 ; 61501462)
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000405436800012
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15257
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Thorac Surg, Beijing, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Mao, Yamin,Wang, Kun,He, Kunshan,et al. Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery[J]. JOURNAL OF BIOMEDICAL OPTICS,2017,22(6).
APA Mao, Yamin.,Wang, Kun.,He, Kunshan.,Ye, Jinzuo.,Yang, Fan.,...&Tian, Jie.(2017).Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery.JOURNAL OF BIOMEDICAL OPTICS,22(6).
MLA Mao, Yamin,et al."Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery".JOURNAL OF BIOMEDICAL OPTICS 22.6(2017).
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