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Altered resting state functional connectivity of anterior insula in young smokers
Bi, Yanzhi1,2; Yuan, Kai1,2,3; Guan, Yanyan1,2; Cheng, Jiadong1,2; Zhang, Yajuan1,2; Li, Yangding1,2; Yu, Dahua3; Qin, Wei1,2; Tian, Jie1,2,4
2017-02-01
发表期刊BRAIN IMAGING AND BEHAVIOR
卷号11期号:1页码:155-165
文章类型Article
摘要The insula has been implicated in cognitive control and craving, all of which are critical to the clinical manifestations of nicotine dependence. However, little evidence exists about the abnormalities in resting state functional connectivity (RSFC) of the insula in young smokers, which might improve our understanding of the neural mechanisms of nicotine dependence. Due to the structural and functional heterogeneity of the insula, the RSFC patterns of both left and right anterior (AI) and posterior insula (PI) were investigated in young smokers and non-smokers. Meanwhile, the relationship was assessed between the neuroimaging findings and clinical information (pack-years, FTND, and craving) as well as cognitive control deficits measured by Stroop task performance. Compared with non-smokers, young smokers showed reduced RSFC between right AI and anterior cingulate cortex (ACC), ventromedial prefrontal cortex (VMPFC), amygdala, left dorsolateral prefrontal cortex, and dorsal striatum. Additionally, left AI showed reduced RSFC with ACC. Both left and right PI network differences were not observed between two groups. Moreover, in young smokers, FTND and incongruent errors in the Stroop task were negatively correlated with the RSFC between AI and ACC. Craving scores showed a significantly negative relationship with the RSFC strength between right AI and left VMPFC. These results provide a more thorough network-level understanding the role of insula in cigarette smoking. The findings provide new insights into the roles of AI-ACC circuit in cognitive control deficits and right AI-VMPFC circuit relevant to the craving of nicotine dependence for young smokers.
关键词Insula Resting State Functional Connectivity Young Smokers Cognitive Control Craving
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-016-9511-z
关键词[WOS]TRANSCRANIAL MAGNETIC STIMULATION ; OLD-WORLD MONKEY ; SMOKING CUES ; NICOTINE DEPENDENCE ; CIGARETTE-SMOKING ; COGNITIVE CONTROL ; CINGULATE CORTEX ; BRAIN ; FMRI ; ADDICTION
收录类别SCI
语种英语
项目资助者Project for the National Key Basic Research and Development Program(2014CB543203 ; National Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; General Financial Grant China Post-doctoral Science Foundation(2014 M552416) ; 2011CB707700 ; 81571753 ; JB121405) ; 2014QDL002) ; 2012CB518501) ; 61502376 ; 81401478 ; 81401488 ; 81271644 ; 81271546 ; 81271549 ; 81470816 ; 81471737 ; 81301281)
WOS研究方向Neurosciences & Neurology
WOS类目Neuroimaging
WOS记录号WOS:000400575300013
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15259
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Inner Mongolia, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
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Bi, Yanzhi,Yuan, Kai,Guan, Yanyan,et al. Altered resting state functional connectivity of anterior insula in young smokers[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(1):155-165.
APA Bi, Yanzhi.,Yuan, Kai.,Guan, Yanyan.,Cheng, Jiadong.,Zhang, Yajuan.,...&Tian, Jie.(2017).Altered resting state functional connectivity of anterior insula in young smokers.BRAIN IMAGING AND BEHAVIOR,11(1),155-165.
MLA Bi, Yanzhi,et al."Altered resting state functional connectivity of anterior insula in young smokers".BRAIN IMAGING AND BEHAVIOR 11.1(2017):155-165.
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