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Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder
Yuan, Kai1,2,3; Yu, Dahua3; Cai, Chenxi1,2; Feng, Dan1,2; Li, Yangding1,2; Bi, Yanzhi1,2; Liu, Jixin1,2; Zhang, Yi1,2; Jin, Chenwang4; Li, Linling5; Qin, Wei1,2; Tian, Jie1,2,6
AbstractConverging evidence has identified cognitive control deficits in internet gaming disorder (IGD). Recently, mounting evidence had revealed that resting state functional connectivity (RSFC) and structural connectivity of frontostriatal circuits could modulate cognitive control in healthy individuals. Unfortunately, relatively little is known about the thoroughly circuit-level characterization of the frontostriatal pathways (both the dorsal and ventral striatum) during resting-state and their association with cognitive control in IGD. In the current study, the differences of striatum volume and RSFC networks were investigated between 43 young IGD individuals and 44 healthy controls. Meanwhile, cognitive control deficits were assessed by Stroop task performances. The neuroimaging findings were then correlated with the Stroop task behaviors. In IGD subjects, we demonstrated an increased volume of right caudate and nucleus accumbens (NAc) as well as reduced RSFC strength of dorsal prefrontal cortex (DLPFC)-caudate and orbitofrontal cortex (OFC)-NAc. NAc volumes were positively correlated with internet addiction test scores in IGD. The caudate volume and DLPFC-caudate RSFC was correlated with the impaired cognitive control (more incongruent errors in Stroop task) in IGD. Consistent with substance use disorder (SUD) findings, we detected striatum volume and frontostriatal circuits RSFC differences between IGD and healthy controls, which provided evidence of some degree of the similarity between IGD and SUD. More importantly, the cognitive control deficits in IGD were correlated with the reduced frontostrital RSFC strength. It is hoped that our results could shed insight on the neurobiological mechanisms of IGD and suggest potential novel therapeutic targets for treatment.
KeywordCognitive Control Frontostriatal Circuits Internet Gaming Disorder Mediation Analysis Resting-state Functional Connectivity Striatum
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI ; SSCI
Funding OrganizationNational Natural Science Foundation of China(81571751 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(JB151204 ; Natural Science Foundation of Inner Mongolia(2014BS0610) ; Innovation Fund Project of Inner Mongolia University of Science and Technology(2015QNGG03 ; General Financial Grant the China Post-doctoral Science Foundation(2014M552416) ; 81571753 ; JB121405) ; 2014QDL002) ; 61502376 ; 81401478 ; 81401488 ; 8147 0816 ; 81471737 ; 81301281 ; 81271546 ; 8127 1549)
WOS Research AreaBiochemistry & Molecular Biology ; Substance Abuse
WOS SubjectBiochemistry & Molecular Biology ; Substance Abuse
WOS IDWOS:000400600700018
Citation statistics
Cited Times:89[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Xidian Univ, Sch Life Sci & Technol, 266 Xinglong Sect Xifeng Rd, Xian 710126, Shaanxi, Peoples R China
2.Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian, Peoples R China
3.Inner Mongolia Univ Sci & Technol, Sch Informat Engn, Informat Proc Lab, Baotou, Peoples R China
4.Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Med Imaging, Xian, Peoples R China
5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Kai,Yu, Dahua,Cai, Chenxi,et al. Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder[J]. ADDICTION BIOLOGY,2017,22(3):813-822.
APA Yuan, Kai.,Yu, Dahua.,Cai, Chenxi.,Feng, Dan.,Li, Yangding.,...&Tian, Jie.(2017).Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder.ADDICTION BIOLOGY,22(3),813-822.
MLA Yuan, Kai,et al."Frontostriatal circuits, resting state functional connectivity and cognitive control in internet gaming disorder".ADDICTION BIOLOGY 22.3(2017):813-822.
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