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Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis
Zhang, Yuanchao1; Fang, Tao1; Wang, Yue1; Guo, Xin1; Alarefi, Abdulqawi1; Wang, Jian2; Jiang, Tianzi1,3; Zhang, Jiuquan2
Source PublicationBRAIN IMAGING AND BEHAVIOR
2017-02-01
Volume11Issue:1Pages:1-7
SubtypeArticle
AbstractAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the present study, we applied a surface-based local gyrification index (LGI) from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls. Using resting-state fMRI data, we further conducted seed-based functional connectivity analysis to explore the functional correlate of the cortical folding changes. We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus. This set of findings was speculated to result from disturbed white matter connectivity in ALS. In the patient group, we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus, which may reflect the cognitive deterioration in ALS. In summary, our results suggest that LGI may provide a useful means to assess ALS-related neurodegeneration and to study the pathophysiology of ALS.
KeywordAmyotrophic Lateral Sclerosis Cortical Folding Local Gyrification Index Functional Connectivity White Matter Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1007/s11682-015-9499-9
WOS KeywordMILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; FDG-PET ; SURFACE-AREA ; ALS-FTD ; BRAIN ; THICKNESS ; WIDESPREAD ; DEFICITS ; CRITERIA
Indexed BySCI
Language英语
Funding OrganizationNational Basic Research Program of China (973 program)(2011CB707800) ; Natural Science Foundation of China(81101000) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014)
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeuroimaging
WOS IDWOS:000400575300001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15270
Collection脑网络组研究中心
Affiliation1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China
2.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yuanchao,Fang, Tao,Wang, Yue,et al. Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(1):1-7.
APA Zhang, Yuanchao.,Fang, Tao.,Wang, Yue.,Guo, Xin.,Alarefi, Abdulqawi.,...&Zhang, Jiuquan.(2017).Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.BRAIN IMAGING AND BEHAVIOR,11(1),1-7.
MLA Zhang, Yuanchao,et al."Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis".BRAIN IMAGING AND BEHAVIOR 11.1(2017):1-7.
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