Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis

doi:10.1007/s11682-015-9499-9

	Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis
	Zhang, Yuanchao 1; Fang, Tao 1; Wang, Yue 1; Guo, Xin 1; Alarefi, Abdulqawi 1; Wang, Jian 2; Jiang, Tianzi1,3 ; Zhang, Jiuquan 2
发表期刊	BRAIN IMAGING AND BEHAVIOR
	2017-02-01
卷号	11 期号:1 页码:1-7
文章类型	Article
摘要	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the present study, we applied a surface-based local gyrification index (LGI) from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls. Using resting-state fMRI data, we further conducted seed-based functional connectivity analysis to explore the functional correlate of the cortical folding changes. We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus. This set of findings was speculated to result from disturbed white matter connectivity in ALS. In the patient group, we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus, which may reflect the cognitive deterioration in ALS. In summary, our results suggest that LGI may provide a useful means to assess ALS-related neurodegeneration and to study the pathophysiology of ALS.
关键词	Amyotrophic Lateral Sclerosis Cortical Folding Local Gyrification Index Functional Connectivity White Matter Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1007/s11682-015-9499-9
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; WHITE-MATTER ; FDG-PET ; SURFACE-AREA ; ALS-FTD ; BRAIN ; THICKNESS ; WIDESPREAD ; DEFICITS ; CRITERIA
收录类别	SCI
语种	英语
项目资助者	National Basic Research Program of China (973 program)(2011CB707800) ; Natural Science Foundation of China(81101000) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014)
WOS研究方向	Neurosciences & Neurology
WOS类目	Neuroimaging
WOS记录号	WOS:000400575300001
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15270
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 2.Third Mil Med Univ, Southwest Hosp, Dept Radiol, Chongqing 400038, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yuanchao,Fang, Tao,Wang, Yue,et al. Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis[J]. BRAIN IMAGING AND BEHAVIOR,2017,11(1):1-7.
APA	Zhang, Yuanchao.,Fang, Tao.,Wang, Yue.,Guo, Xin.,Alarefi, Abdulqawi.,...&Zhang, Jiuquan.(2017).Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis.BRAIN IMAGING AND BEHAVIOR,11(1),1-7.
MLA	Zhang, Yuanchao,et al."Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis".BRAIN IMAGING AND BEHAVIOR 11.1(2017):1-7.