CASIA OpenIR  > 中国科学院分子影像重点实验室
Granger causality reveals a dominant role of memory circuit in chronic opioid dependence
Zhang, Yi1,2,3; Li, Qiang4; Wen, Xiaotong5; Cai, Weiwei1; Li, Guanya1; Tian, Jie1,6; Zhang, Yi Edi2,3,7; Liu, Jixin1; Yuan, Kai1; Zhao, Jizheng8; Wang, Wei4; Zhou, Zhenyu4; Ding, Mingzhou9; Gold, Mark S.2,3; Liu, Yijun2,3; Wang, Gene-Jack10
Source PublicationADDICTION BIOLOGY
2017-07-01
Volume22Issue:4Pages:1068-1080
SubtypeArticle
AbstractResting-state magnetic resonance imaging has uncovered abnormal functional connectivity in heroin-dependent individuals (HDIs). However, it remains unclear how brain regions implicated in addictions are related in baseline state without conditioned cues in heroin dependent individuals during opioid maintenance treatment (HDIs-OMT). Previous connectivity analysis assessed the strength of correlated activity between brain regions but lacked the ability to infer directional neural interactions. In the current study, we employed Granger causality analysis to investigate directional causal influences among the brain circuits in HDIs-OMT and non-opioid users. The results revealed a weaker effective connectivity between the caudate nucleus implicated in mediating the reward circuit and other brain regions and also a weaker connectivity between the anterior cingulate cortex and medial prefrontal cortex implicated in mediating inhibitory control. Conversely, HDIs-OMT exhibited stronger effective connectivity between the hippocampus and amygdala implicated in mediating learning-memory, and the anterior cingulate cortex involved in mediating inhibitory control while the putamen mediated learned habits, suggesting that the hippocampus and amygdala may propel the memory circuit to override the control circuit and drive the learned habit in HDIs-OMT. Alterations in learning-memory and inhibitory control may contribute jointly and form a basis for relapse risk even after a period of heroin abstinence. Sustained neural effect of opioid dependence on methadone maintenance including hyperactivation in the memory circuit and impairment in the control circuit support the role of the memory circuitry in relapse and may help redefine targets for treatment.
KeywordGranger Causality Inhibitory Control Learning-memory Opioid Dependence Resting-state Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1111/adb.12390
WOS KeywordINDUCED BRAIN ACTIVATION ; HEROIN-RELATED CUES ; DOPAMINE RELEASE ; COCAINE ADDICTION ; FUNCTIONAL MRI ; NEUROIMAGING EVIDENCE ; RESPONSE-INHIBITION ; NEURONAL MECHANISMS ; ALPHA OSCILLATIONS ; DRUG-ADDICTION
Indexed BySCI ; SSCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81271549 ; Shaanxi Provincial Natural Science Foundation(2015JM3117) ; Project for the National Key Basic Research and Development Program (973)(2011CB707700) ; Fundamental Research Funds for the Central Universities ; Scientific Research Funds for Renmin University of China(14XNLF11 ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1216) ; 81470816 ; 15XNQ037 ; 61431013 ; 15XNLQ05) ; 61131003 ; 81201081 ; 31400973 ; 81571751 ; 81571753)
WOS Research AreaBiochemistry & Molecular Biology ; Substance Abuse
WOS SubjectBiochemistry & Molecular Biology ; Substance Abuse
WOS IDWOS:000406076800017
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15279
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA
3.Univ Florida, McKnight Brain Inst, Gainesville, FL USA
4.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, 10 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
5.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
7.Malcom Randall Vet Affairs Med Ctr, Gainesville, FL USA
8.Northwest A&F Univ, Coll Mech & Elect Engn, Yangling, Peoples R China
9.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA
10.NIAAA, Lab Neuroimaging, Bethesda, MD USA
Recommended Citation
GB/T 7714
Zhang, Yi,Li, Qiang,Wen, Xiaotong,et al. Granger causality reveals a dominant role of memory circuit in chronic opioid dependence[J]. ADDICTION BIOLOGY,2017,22(4):1068-1080.
APA Zhang, Yi.,Li, Qiang.,Wen, Xiaotong.,Cai, Weiwei.,Li, Guanya.,...&Wang, Gene-Jack.(2017).Granger causality reveals a dominant role of memory circuit in chronic opioid dependence.ADDICTION BIOLOGY,22(4),1068-1080.
MLA Zhang, Yi,et al."Granger causality reveals a dominant role of memory circuit in chronic opioid dependence".ADDICTION BIOLOGY 22.4(2017):1068-1080.
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