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Granger causality reveals a dominant role of memory circuit in chronic opioid dependence
Zhang, Yi1,2,3; Li, Qiang4; Wen, Xiaotong5; Cai, Weiwei1; Li, Guanya1; Tian, Jie1,6; Zhang, Yi Edi2,3,7; Liu, Jixin1; Yuan, Kai1; Zhao, Jizheng8; Wang, Wei4; Zhou, Zhenyu4; Ding, Mingzhou9; Gold, Mark S.2,3; Liu, Yijun2,3; Wang, Gene-Jack10
2017-07-01
发表期刊ADDICTION BIOLOGY
卷号22期号:4页码:1068-1080
文章类型Article
摘要Resting-state magnetic resonance imaging has uncovered abnormal functional connectivity in heroin-dependent individuals (HDIs). However, it remains unclear how brain regions implicated in addictions are related in baseline state without conditioned cues in heroin dependent individuals during opioid maintenance treatment (HDIs-OMT). Previous connectivity analysis assessed the strength of correlated activity between brain regions but lacked the ability to infer directional neural interactions. In the current study, we employed Granger causality analysis to investigate directional causal influences among the brain circuits in HDIs-OMT and non-opioid users. The results revealed a weaker effective connectivity between the caudate nucleus implicated in mediating the reward circuit and other brain regions and also a weaker connectivity between the anterior cingulate cortex and medial prefrontal cortex implicated in mediating inhibitory control. Conversely, HDIs-OMT exhibited stronger effective connectivity between the hippocampus and amygdala implicated in mediating learning-memory, and the anterior cingulate cortex involved in mediating inhibitory control while the putamen mediated learned habits, suggesting that the hippocampus and amygdala may propel the memory circuit to override the control circuit and drive the learned habit in HDIs-OMT. Alterations in learning-memory and inhibitory control may contribute jointly and form a basis for relapse risk even after a period of heroin abstinence. Sustained neural effect of opioid dependence on methadone maintenance including hyperactivation in the memory circuit and impairment in the control circuit support the role of the memory circuitry in relapse and may help redefine targets for treatment.
关键词Granger Causality Inhibitory Control Learning-memory Opioid Dependence Resting-state Fmri
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1111/adb.12390
关键词[WOS]INDUCED BRAIN ACTIVATION ; HEROIN-RELATED CUES ; DOPAMINE RELEASE ; COCAINE ADDICTION ; FUNCTIONAL MRI ; NEUROIMAGING EVIDENCE ; RESPONSE-INHIBITION ; NEURONAL MECHANISMS ; ALPHA OSCILLATIONS ; DRUG-ADDICTION
收录类别SCI ; SSCI
语种英语
项目资助者National Natural Science Foundation of China(81271549 ; Shaanxi Provincial Natural Science Foundation(2015JM3117) ; Project for the National Key Basic Research and Development Program (973)(2011CB707700) ; Fundamental Research Funds for the Central Universities ; Scientific Research Funds for Renmin University of China(14XNLF11 ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1216) ; 81470816 ; 15XNQ037 ; 61431013 ; 15XNLQ05) ; 61131003 ; 81201081 ; 31400973 ; 81571751 ; 81571753)
WOS研究方向Biochemistry & Molecular Biology ; Substance Abuse
WOS类目Biochemistry & Molecular Biology ; Substance Abuse
WOS记录号WOS:000406076800017
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15279
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA
3.Univ Florida, McKnight Brain Inst, Gainesville, FL USA
4.Fourth Mil Med Univ, Tangdu Hosp, Dept Radiol, 10 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China
5.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
7.Malcom Randall Vet Affairs Med Ctr, Gainesville, FL USA
8.Northwest A&F Univ, Coll Mech & Elect Engn, Yangling, Peoples R China
9.Univ Florida, J Crayton Pruitt Family Dept Biomed Engn, Gainesville, FL USA
10.NIAAA, Lab Neuroimaging, Bethesda, MD USA
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Zhang, Yi,Li, Qiang,Wen, Xiaotong,et al. Granger causality reveals a dominant role of memory circuit in chronic opioid dependence[J]. ADDICTION BIOLOGY,2017,22(4):1068-1080.
APA Zhang, Yi.,Li, Qiang.,Wen, Xiaotong.,Cai, Weiwei.,Li, Guanya.,...&Wang, Gene-Jack.(2017).Granger causality reveals a dominant role of memory circuit in chronic opioid dependence.ADDICTION BIOLOGY,22(4),1068-1080.
MLA Zhang, Yi,et al."Granger causality reveals a dominant role of memory circuit in chronic opioid dependence".ADDICTION BIOLOGY 22.4(2017):1068-1080.
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