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Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment
Zhou, Fubo1; Shang, Wenting2; Yu, Xiaoling1; Tian, Jie2
2018-03-01
发表期刊MEDICINAL RESEARCH REVIEWS
卷号38期号:2页码:741-767
文章类型Review
摘要Liver cancer is the second leading cause of cancer-related deaths, and hepatocellular carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently required for the early detection of HCC and the development of novel therapeutic approaches. Glypican-3 (GPC3), an oncofetal proteoglycan anchored to the cellmembrane, is normally detected in the fetal liver but not in the healthy adult liver. However, in HCC patients, GPC3 is overexpressed at both the gene and protein levels, and its expression predicts a poor prognosis. Mechanistic studies have revealed that GPC3 functions in HCC progression by binding to molecules such as Wnt signaling proteins and growth factors. Moreover, GPC3 has been used as a target for molecular imaging and therapeutic intervention in HCC. To date, GPC3-targeted magnetic resonance imaging, positron emission tomography, and near-infrared imaging have been investigated for early HCC detection, and various immunotherapeutic protocols targeting GPC3 have been developed, including the use of humanized anti-GPC3 cytotoxic antibodies, treatment with peptide/DNA vaccines, immunotoxin therapies, and genetic therapies. In this review, we summarize the current knowledge regarding the structure, function, and biology of GPC3 with a focus on its clinical potential as a diagnostic molecule and a therapeutic target in HCC immunotherapy.
关键词Glypican-3 Hepatocellular Carcinoma
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/med.21455
关键词[WOS]CYTOTOXIC T-LYMPHOCYTES ; EPITHELIAL-MESENCHYMAL TRANSITION ; GOLABI-BEHMEL-SYNDROME ; LIVER-CANCER THERAPY ; TARGETING GLYPICAN-3 ; POOR-PROGNOSIS ; CELL-PROLIFERATION ; SERUM GLYPICAN-3 ; ALPHA-FETOPROTEIN ; CLINICAL UTILITY
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(81471683 ; National Science and Technology Major Project of China(2017ZX10203204-008) ; 81671710)
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000425027400010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15424
专题中国科学院分子影像重点实验室
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,et al. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment[J]. MEDICINAL RESEARCH REVIEWS,2018,38(2):741-767.
APA Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,&Tian, Jie.(2018).Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment.MEDICINAL RESEARCH REVIEWS,38(2),741-767.
MLA Zhou, Fubo,et al."Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment".MEDICINAL RESEARCH REVIEWS 38.2(2018):741-767.
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