Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment

doi:10.1002/med.21455

	Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment
	Zhou, Fubo 1; Shang, Wenting2 ; Yu, Xiaoling 1; Tian, Jie 2
发表期刊	MEDICINAL RESEARCH REVIEWS
	2018-03-01
卷号	38 期号:2 页码:741-767
文章类型	Review
摘要	Liver cancer is the second leading cause of cancer-related deaths, and hepatocellular carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently required for the early detection of HCC and the development of novel therapeutic approaches. Glypican-3 (GPC3), an oncofetal proteoglycan anchored to the cellmembrane, is normally detected in the fetal liver but not in the healthy adult liver. However, in HCC patients, GPC3 is overexpressed at both the gene and protein levels, and its expression predicts a poor prognosis. Mechanistic studies have revealed that GPC3 functions in HCC progression by binding to molecules such as Wnt signaling proteins and growth factors. Moreover, GPC3 has been used as a target for molecular imaging and therapeutic intervention in HCC. To date, GPC3-targeted magnetic resonance imaging, positron emission tomography, and near-infrared imaging have been investigated for early HCC detection, and various immunotherapeutic protocols targeting GPC3 have been developed, including the use of humanized anti-GPC3 cytotoxic antibodies, treatment with peptide/DNA vaccines, immunotoxin therapies, and genetic therapies. In this review, we summarize the current knowledge regarding the structure, function, and biology of GPC3 with a focus on its clinical potential as a diagnostic molecule and a therapeutic target in HCC immunotherapy.
关键词	Glypican-3 Hepatocellular Carcinoma
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1002/med.21455
关键词[WOS]	CYTOTOXIC T-LYMPHOCYTES ; EPITHELIAL-MESENCHYMAL TRANSITION ; GOLABI-BEHMEL-SYNDROME ; LIVER-CANCER THERAPY ; TARGETING GLYPICAN-3 ; POOR-PROGNOSIS ; CELL-PROLIFERATION ; SERUM GLYPICAN-3 ; ALPHA-FETOPROTEIN ; CLINICAL UTILITY
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81471683 ; National Science and Technology Major Project of China(2017ZX10203204-008) ; 81671710)
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000425027400010
引用统计	被引频次：209[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15424
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,et al. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment[J]. MEDICINAL RESEARCH REVIEWS,2018,38(2):741-767.
APA	Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,&Tian, Jie.(2018).Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment.MEDICINAL RESEARCH REVIEWS,38(2),741-767.
MLA	Zhou, Fubo,et al."Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment".MEDICINAL RESEARCH REVIEWS 38.2(2018):741-767.

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