CASIA OpenIR  > 中国科学院分子影像重点实验室
Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment
Zhou, Fubo1; Shang, Wenting2; Yu, Xiaoling1; Tian, Jie2
Source PublicationMEDICINAL RESEARCH REVIEWS
2018-03-01
Volume38Issue:2Pages:741-767
SubtypeReview
AbstractLiver cancer is the second leading cause of cancer-related deaths, and hepatocellular carcinoma (HCC) is the most common type. Therefore, molecular targets are urgently required for the early detection of HCC and the development of novel therapeutic approaches. Glypican-3 (GPC3), an oncofetal proteoglycan anchored to the cellmembrane, is normally detected in the fetal liver but not in the healthy adult liver. However, in HCC patients, GPC3 is overexpressed at both the gene and protein levels, and its expression predicts a poor prognosis. Mechanistic studies have revealed that GPC3 functions in HCC progression by binding to molecules such as Wnt signaling proteins and growth factors. Moreover, GPC3 has been used as a target for molecular imaging and therapeutic intervention in HCC. To date, GPC3-targeted magnetic resonance imaging, positron emission tomography, and near-infrared imaging have been investigated for early HCC detection, and various immunotherapeutic protocols targeting GPC3 have been developed, including the use of humanized anti-GPC3 cytotoxic antibodies, treatment with peptide/DNA vaccines, immunotoxin therapies, and genetic therapies. In this review, we summarize the current knowledge regarding the structure, function, and biology of GPC3 with a focus on its clinical potential as a diagnostic molecule and a therapeutic target in HCC immunotherapy.
KeywordGlypican-3 Hepatocellular Carcinoma
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1002/med.21455
WOS KeywordCYTOTOXIC T-LYMPHOCYTES ; EPITHELIAL-MESENCHYMAL TRANSITION ; GOLABI-BEHMEL-SYNDROME ; LIVER-CANCER THERAPY ; TARGETING GLYPICAN-3 ; POOR-PROGNOSIS ; CELL-PROLIFERATION ; SERUM GLYPICAN-3 ; ALPHA-FETOPROTEIN ; CLINICAL UTILITY
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81471683 ; National Science and Technology Major Project of China(2017ZX10203204-008) ; 81671710)
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000425027400010
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15424
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,et al. Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment[J]. MEDICINAL RESEARCH REVIEWS,2018,38(2):741-767.
APA Zhou, Fubo,Shang, Wenting,Yu, Xiaoling,&Tian, Jie.(2018).Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment.MEDICINAL RESEARCH REVIEWS,38(2),741-767.
MLA Zhou, Fubo,et al."Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment".MEDICINAL RESEARCH REVIEWS 38.2(2018):741-767.
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