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From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer
Tianpei Guan1,2,3,4; Wenting Shang2,3; Hui Li2,3; Xin Yang2,3; Chihua Fang1; Jie Tian2,3; Kun Wang2,3
2017
发表期刊Bioconjugate Chemistry
卷号4期号:28页码:1221-1228
摘要Conventional imaging methods encounter challenges in diagnosing liver cancer that is
less than 10 mm and/or without typical hypervascular features. With deep penetration
and high spatial resolution imaging capability, the emerging photoacoustic
tomography may offer better diagnostic efficacy for non-invasive liver cancer
detection. Moreover, near-infrared fluorescence imaging guided hepatectomy was
proven to be able to identify nodules at millimeter level. Thus, suitable photoacoustic
and fluorescence dual-modality imaging probe may benefit patients in early diagnosis
and complete resection. In this study, we fabricated indocyanine green loaded gold
nanorod@liposome core-shell nanoparticles (Au@liposome-ICG) to integrate both
imaging strategies. These nanoparticles exhibit superior biocompatibility, high
stability, and enhanced dual-model imaging signal. Then, we explored its
effectiveness of tumor detection and surgery guidance in orthotopic liver cancer
mouse models. Histological analysis confirmed the accuracy of the probe in liver
cancer detection and resection. This novel dual-modality nano-probe holds promise
for early diagnosis and better surgical outcome of liver cancer and has great potential
for clinical translation.
关键词Photoacoustic Tomography Fluorescence Imaging Au Nanorods Liver Cancer Tumor Detection Surgery Guidance
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15425
专题中国科学院分子影像重点实验室
作者单位1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical
2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese
3.Beijing Key Laboratory of Molecular Imaging, Beijing 100190, China.
4.Guangdong provincial clinical and engineering center of digital medicine,
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GB/T 7714
Tianpei Guan,Wenting Shang,Hui Li,et al. From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer[J]. Bioconjugate Chemistry,2017,4(28):1221-1228.
APA Tianpei Guan.,Wenting Shang.,Hui Li.,Xin Yang.,Chihua Fang.,...&Kun Wang.(2017).From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer.Bioconjugate Chemistry,4(28),1221-1228.
MLA Tianpei Guan,et al."From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Au@liposome-ICG Nanoparticles in Liver Cancer".Bioconjugate Chemistry 4.28(2017):1221-1228.
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