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A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
Hu, Yanyan1,2; Chi, Chongwei2; Wang, Shunhao3,4,5; Wang, Lingxiong6; Liang, Ping1; Liu, Fangyi1; Shang, Wenting2; Wang, Weiwei3; Zhang, Fengrong3; Li, Shanshan3; Shen, Heyun3; Yu, Xiaoling1; Liu, Huiyu3; Tian, Jie2,5
2017-09-06
发表期刊ADVANCED MATERIALS
卷号29期号:33页码:1-9
文章类型Article
摘要Although nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (I-125) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.
关键词Active Targeting Clinical Intervention Gold Nanoshells Interventional Photothermal Therapy Pancreatic Cancer
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201700448
关键词[WOS]HEAT CONVERSION EFFICIENCY ; TRIPLE-COMBINATION THERAPY ; GOLD NANOPARTICLES ; SILICA NANORATTLES ; IN-VIVO ; CARBON NANOTUBES ; METASTASIS ; NANOSHELLS ; LIGHT ; IMMUNOTHERAPY
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(51572271 ; National Basic Research Program of China (973 Program)(2016YFA0201500) ; Fundamental Research Funds for the Central Universities(buctrc201610 ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; 81471683 ; JD1609 ; 81671710 ; PYBZ1705) ; 81227901 ; 81527805 ; 61501462)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号WOS:000408933600008
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15426
专题中国科学院分子影像重点实验室
作者单位1.Gen Hosp Peoples Liberat Army, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, State Key Lab Chem Resource Engn, Bionanomat & Translat Engn Lab,Beijing Key Lab Bi, Beijing 100029, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Gen Hosp Peoples Liberat Army, Div Internal Med, Canc Ctr Lab, Beijing 100853, Peoples R China
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GB/T 7714
Hu, Yanyan,Chi, Chongwei,Wang, Shunhao,et al. A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer[J]. ADVANCED MATERIALS,2017,29(33):1-9.
APA Hu, Yanyan.,Chi, Chongwei.,Wang, Shunhao.,Wang, Lingxiong.,Liang, Ping.,...&Tian, Jie.(2017).A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer.ADVANCED MATERIALS,29(33),1-9.
MLA Hu, Yanyan,et al."A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer".ADVANCED MATERIALS 29.33(2017):1-9.
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