CASIA OpenIR  > 中国科学院分子影像重点实验室
A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer
Hu, Yanyan1,2; Chi, Chongwei2; Wang, Shunhao3,4,5; Wang, Lingxiong6; Liang, Ping1; Liu, Fangyi1; Shang, Wenting2; Wang, Weiwei3; Zhang, Fengrong3; Li, Shanshan3; Shen, Heyun3; Yu, Xiaoling1; Liu, Huiyu3; Tian, Jie2,5
AbstractAlthough nanoparticle-based photothermal therapy (PTT) has been intensively investigated recently, its comparative efficiency with any clinical cancer treatments has been rarely explored. Herein for the first time we report a systematic comparative study of clinical iodine-125 (I-125) interstitial brachytherapy (IBT-125-I) and interventional PTT (IPTT) in an orthotopic xenograft model of human pancreatic cancer. IPTT, based on the nanoparticles composing of anti-urokinase plasminogen activator receptor (uPAR) antibody, polyethylene glycol (PEG), and indocyanine green (ICG) modified gold nanoshells (hereinafter uIGNs), is directly applied to local pancreatic tumor deep in the abdomen. In comparison to IBT-125-I, a 25% higher median survival rate of IPTT with complete ablation by one-time intervention has been achieved. The IPTT could also inhibit pancreatic tumor metastasis which can be harnessed for effective cancer immunotherapy. All results show that this IPTT is a safe and radical treatment for eradicating tumor cells, and may benefit future clinical pancreatic cancer patients.
KeywordActive Targeting Clinical Intervention Gold Nanoshells Interventional Photothermal Therapy Pancreatic Cancer
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
Funding OrganizationNational Natural Science Foundation of China(51572271 ; National Basic Research Program of China (973 Program)(2016YFA0201500) ; Fundamental Research Funds for the Central Universities(buctrc201610 ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; 81471683 ; JD1609 ; 81671710 ; PYBZ1705) ; 81227901 ; 81527805 ; 61501462)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000408933600008
Citation statistics
Cited Times:50[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Gen Hosp Peoples Liberat Army, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, State Key Lab Chem Resource Engn, Bionanomat & Translat Engn Lab,Beijing Key Lab Bi, Beijing 100029, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Gen Hosp Peoples Liberat Army, Div Internal Med, Canc Ctr Lab, Beijing 100853, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Hu, Yanyan,Chi, Chongwei,Wang, Shunhao,et al. A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer[J]. ADVANCED MATERIALS,2017,29(33):1-9.
APA Hu, Yanyan.,Chi, Chongwei.,Wang, Shunhao.,Wang, Lingxiong.,Liang, Ping.,...&Tian, Jie.(2017).A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer.ADVANCED MATERIALS,29(33),1-9.
MLA Hu, Yanyan,et al."A Comparative Study of Clinical Intervention and Interventional Photothermal Therapy for Pancreatic Cancer".ADVANCED MATERIALS 29.33(2017):1-9.
Files in This Item: Download All
File Name/Size DocType Version Access License
A Comparative Study (4338KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, Yanyan]'s Articles
[Chi, Chongwei]'s Articles
[Wang, Shunhao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, Yanyan]'s Articles
[Chi, Chongwei]'s Articles
[Wang, Shunhao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, Yanyan]'s Articles
[Chi, Chongwei]'s Articles
[Wang, Shunhao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: A Comparative Study of Clinical Intervention and.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.